ABL1

Gene Symbol ABL1
Entrez Gene 25
Alt Symbol ABL, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl
Species Human
Gene Type protein-coding
Description ABL proto-oncogene 1, non-receptor tyrosine kinase
Other Description Abelson tyrosine-protein kinase 1|bcr/c-abl oncogene protein|c-abl oncogene 1, receptor tyrosine kinase|proto-oncogene c-Abl|proto-oncogene tyrosine-protein kinase ABL1|tyrosine-protein kinase ABL1|v-abl Abelson murine leukemia viral oncogene homolog 1
Swissprots Q16133 Q45F09 Q13870 P00519 Q17R61 Q13869 A3KFJ3
Accessions AAA35593 AAA51895 AAB60393 AAB60394 AAD14034 AAZ38718 AHX39209 CAP08044 EAW87947 EAW87948 EAW87949 P00519 AA524892 AB209456 BAD92693 AB209642 BAD92879 AI458416 AK294983 BAG58052 AL707819 BC107069 AAI07070 BC107070 AAI07071 BC117451 AAI17452 CA335983 FJ785401 ACN82441 JF272500 ADX30694 JX565024 AFV09100 JX565025 AFV09101 M14752 AAA51561 M14753 AAA51562 M14754 AAA51563 M30833 AAA88011 X16416 CAA34438 X51945 NM_005157 NP_005148 NM_007313 NP_009297
Function Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses thro
Subcellular Location Cytoplasm, cytoskeleton. Nucleus. Mitochondrion {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity). {ECO:0000250}.
Tissue Specificity Widely expressed.
Top Pathways Cell cycle, Neurotrophin signaling pathway, ErbB signaling pathway, Pathogenic Escherichia coli infection, Chronic myeloid leukemia

Phospho-c-Abl (Tyr204) (C42B5) Rabbit mAb - 3009 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C42B5
Western blot analysis of extracts from CML-T1 leukemic cells using Phospho-c-Abl (Tyr204) (C42B5) Rabbit mAb (upper and middle) or c-Abl Antibody #2862 (lower). The phospho-specificity of this rabbit mAb was verified by treating the membrane with calf intestinal phosphatase (CIP) (middle and lower) before antibody probing.

Phospho-c-Abl (Tyr245) Antibody - 2861 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from K562 cells, untreated or treated with an Abl inhibitor, using Phospho-c-Abl (Tyr245) Antibody.

Phospho-c-Abl (Tyr412) (247C7) Rabbit mAb - 2865 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 247C7
Western blot analysis of extracts from cells expressing various activated tyrosine kinase proteins, using Phospho-c-Abl (Tyr412) (247C7 ) Rabbit mAb (upper) or Phospho-Tyrosine mAb (P-Tyr-100) #9411 (lower). Phospho-c-Abl (Tyr412) (247C7 ) Rabbit mAb specifically recognizes the activated Abl of Bcr-Abl fusion proteins, whose phosphorylation was abolished by calf intestinal phosphatase (CIP) treatment.

Phospho-c-Abl (Tyr89) (61A6) Rabbit mAb - 3098 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 61A6
Western blot analysis of extract from CML-T1 leukemic cells with Phospho-c-Abl (Tyr89) (61A6) Rabbit mAb (upper and middle) or c-Abl Antibody #2862 (lower). The phospho-specificity of this rabbit mAb was verified by treating the membrane with calf intestinal phosphatase (CIP) (middle and lower) before antibody probing.

Phospho-c-Abl (Thr735) Antibody - 2864 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, untreated or TPA-treated (200 nM), using Phospho-c-Abl (Thr735) Antibody (upper) or c-Abl Antibody #2862 (lower).

Phospho-c-Abl (Tyr245) (73E5) Rabbit mAb - 2868 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 73E5
Western blot analysis of extracts from cells expressing various activated tyrosine kinase proteins, using Phospho-c-Abl (Tyr245) (73E5) Rabbit mAb (upper) or Phospho-Tyrosine mAb (P-Tyr-100) #9411 (lower).

c-Abl Antibody - 2862 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines, using c-Abl Antibody.

Bcr (A-1) - sc-365728 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcr (A-1): sc-365728. Western blot analysis of Bcr expression in K-562 whole cell lysate.

c-Abl (C-19) - sc-887 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
c-Abl (C-19) : sc-887. Western blot analysis of c-Abl expression in K-562 whole cell lysate.

c-Abl (K-12) - sc-131 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
c-Abl (K-12) : sc-131. Western blot analysis of c-Abl expression in K-562 whole cell lysate.

c-Abl (H-300) - sc-13076 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
c-Abl (H-300): sc-13076. Immunofluorescence staining of normal mouse liver frozen section showing cytoplasmic staining.

c-Abl (SPM328) - sc-52990 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

c-Abl (8E9) - sc-56887 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
c-Abl (8E9): sc-56887. Western blot analysis of c-Abl expression in K-562 whole cell lysate.

p-c-Abl/Arg (Tyr 393/439) - sc-293096 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of c-Abl/Arg phosphorylation expression in HL-60 whole cell lysate (A,B). Blots were probed with p-c-Abl/Arg (Tyr 393/439): sc-293096 pre-incubated with cognate phosphorylated peptide (A,B).

p-c-Abl (7.Tyr 412) - sc-293130 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of c-Abl phosphorylation in untreated (A,C) and lambda protein phosphatase (sc-200312A) treated (B,D) K-562 whole cell lysates. Antibodies tested include p-c-Abl (7.Tyr 412): sc-293130 (A,B) and c-Abl (K-12): sc-131 (C,D).

p-c-Abl (Tyr 412) - sc-101626 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-c-Abl (Tyr 412): sc-101626. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic staining.

p-c-Abl (Thr 735) - sc-109913 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-c Abl (phospho S588) antibody - ab59966 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human breast carcinoma tissue labelled with ab59966 at 1/50 dilution followed by conjugation to the secondary antibody and AEC staining.

Anti-c Abl (phospho T754 + T735) antibody - ab138358 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-c Abl (phospho T754 + T735) antibody (ab138358) at 1/500 dilution + COS7 cell extract treated with EGF 200ng/ml for 30 min at 30 µg

Anti-c Abl (phospho Y134) antibody - ab135539 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Dot blot analysis of ab135539 on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5µg per ml.

Anti-c Abl (phospho Y204) antibody - ab61757 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-c Abl (phospho Y204) antibody (ab61757) at 1/500 dilutionLane 1 : Extracts from COS7 cells treated with Adriamycin (0.5µg/ml, 24 hours).Lane 2 : Extracts from COS7 cells treated with Adriamycin (0.5µg/ml, 24 hours) and the immunising phosphopeptide.

Anti-c Abl (phospho Y245) antibody - ab193223 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-c Abl (phospho Y245) antibody (ab193223) at 1/500 dilutionLane 1 : Insulin treated K562 tissue extractLane 2 : Insulin treated K562 tissue extract with antigen-specific peptide

Anti-c Abl (phospho Y245) antibody - ab195839 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-c Abl (phospho Y245) antibody (ab195839) at 1/500 dilutionLane 1 : Insulin treated K562 whole cell lysate with antigen specific peptideLane 2 : Insulin treated K562 whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-c Abl (phospho Y245) antibody - ab62189 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cells, using ab62189 at a dilution of 1/100-1/500. Samples were untreated (left hand panel) or treated (right hand panel) with the immunizing peptide.

Anti-c Abl (phospho Y412) antibody - ab47315 from Abcam

Prices $380.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab47315 staining human breast carcinoma by IHC-P (left hand panel). The right hand panel shows staining in the presence of phospho-peptide.
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