Gene Symbol | UBE2V2 |
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Entrez Gene | 7336 |
Alt Symbol | DDVIT1, DDVit-1, EDAF-1, EDPF-1, EDPF1, MMS2, UEV-2, UEV2 |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin-conjugating enzyme E2 variant 2 |
Other Description | 1 alpha,25-dihydroxyvitamin D3-inducible|DDVit 1|MMS2 homolog|enterocyte differentiation promoting factor|enterocyte differentiation-associated factor 1|enterocyte differentiation-associated factor EDAF-1|enterocyte differentiation-promoting factor 1|methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of|vitamin D3-inducible protein |
Swissprots | Q15819 |
Accessions | AAY16979 EAW86687 EAW86688 EAW86689 EAW86690 Q15819 AF049140 AAC05381 AK094617 AK123928 AK313447 BAG36236 BC007051 AAH07051 BC016332 AAH16332 BC016710 AAH16710 BC028673 AAH28673 BC062418 AAH62418 BT006744 AAP35390 CR407628 CAG28556 DQ892507 ABM83433 DQ895721 ABM86647 EU176520 ABW03321 EU176662 ABW03463 EU176696 ABW03497 U62136 AAB04758 X98091 CAA66717 XM_005251300 XP_005251357 XM_011517583 XP_011515885 NM_003350 NP_003341 |
Function | Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. {ECO:0000269|PubMed:10089880, ECO:0000269|PubMed:14562038, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:9705497}. |
Tissue Specificity | Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues. {ECO:0000269|PubMed:9199207, ECO:0000269|PubMed:9705497}. |
Mms2 CRISPR/Cas9 KO Plasmid (h) - sc-404777 from Santa Cruz Biotechnology
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Mms2 HDR Plasmid (h) - sc-404777-HDR from Santa Cruz Biotechnology
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Mms2 Double Nickase Plasmid (h) - sc-404777-NIC from Santa Cruz Biotechnology
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Mms2 Double Nickase Plasmid (h2) - sc-404777-NIC-2 from Santa Cruz Biotechnology
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Mms2 CRISPR Activation Plasmid (h) - sc-404777-ACT from Santa Cruz Biotechnology
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Mms2 CRISPR Activation Plasmid (h2) - sc-404777-ACT-2 from Santa Cruz Biotechnology
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Mms2 Lentiviral Activation Particles (h) - sc-404777-LAC from Santa Cruz Biotechnology
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Mms2 Lentiviral Activation Particles (h2) - sc-404777-LAC-2 from Santa Cruz Biotechnology
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Mms2 siRNA (h) - sc-72124 from Santa Cruz Biotechnology
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Mms2 shRNA Plasmid (h) - sc-72124-SH from Santa Cruz Biotechnology
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Mms2 shRNA (h) Lentiviral Particles - sc-72124-V from Santa Cruz Biotechnology
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UEV2 RNAi - H00007336-R01 from Novus Biologicals
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MISSION® esiRNA - EHU087761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22389 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22389 from Sigma-Aldrich
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UBE2V2 siRNA (Human) - CRH5016 from Cohesion Biosciences
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UBE2V2 - MBS8205797 from MyBioSource
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shRNA set against Human UBE2V2 (NM_003350.2) - SHH439220 from Creative biogene
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Human UBE2V2 siRNA - orb265518 from Biorbyt
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UBE2V2 shRNA Plasmid (Human) - CHH5016 from Cohesion Biosciences
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UBE2V2 miRNA 3'UTR clone - MiUTR1H-10960 from Creative biogene
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