| Gene Symbol |
Pafah1b1
|
| Entrez Gene |
18472
|
| Alt Symbol |
LIS-1, Lis1, MMS10-U, Mdsh, Ms10u, Pafaha
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
|
| Other Description |
LIS-1|PAF acetylhydrolase 45 kDa subunit|PAF-AH 45 kDa subunit|PAF-AH alpha|PAFAH alpha|lissencephaly-1 protein|platelet-activating factor acetylhydrolase 1b, regulatory subunit 1|platelet-activating factor acetylhydrolase IB subunit alpha|platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit
|
| Swissprots |
P63005
|
| Accessions |
AAC63098 AAC63099 EDL12776 P63005 AK144908 BAE26129 AK147207 BAE27764 AK147229 AK147237 BAE27787 AK147309 BAE27837 AK147507 BAE27961 AK147515 BAE27965 AK147533 BAE27977 AK147793 BAE28141 AK152284 AK160764 BAE35996 AK161751 AK164008 BAE37586 AK164276 AK167448 BAE39534 AK167824 BAE39846 AK168929 BAE40742 AK168960 BAE40766 AY189217 AAO41716 AY189218 AAO41717 BC014831 AAH14831 BC026141 AAH26141 BC046989 BC099462 BE456911 BQ895724 L25108 L25109 AAD23059 U95116 AAC04610 NM_013625 NP_038653 NR_037610
|
| Function |
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein- mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of loc
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus membrane {ECO:0000255|HAMAP-Rule:MF_03141}. Note=May localize to the nuclear membrane (By similarity). Localizes to the plus end of microtubules and to the centrosome. Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in brain, particularly the hippocampus and the olfactory bulb. Also highly expressed in testis, including all seminiferous tubule cell types, all types of spermatogenic and Sertoli cells, and meiotically dividing and elongating spermatids. Expressed at lower levels in heart, kidney, large intestine, liver, lung, ovary, small intestine and spleen. {ECO:0000269|PubMed:11163259, ECO:0000269|PubMed:11163260, ECO:0000269|PubMed:12551946}.
|
| Top Pathways |
Ether lipid metabolism
|