| Gene Symbol |
Fstl3
|
| Entrez Gene |
114031
|
| Alt Symbol |
Flrg
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
follistatin-like 3 (secreted glycoprotein)
|
| Other Description |
follistatin-like protein 3|follistatin-related gene protein|follistatin-related protein 3
|
| Swissprots |
Q99PW7 Q54A93
|
| Accessions |
EDL89395 Q99PW7 AB021295 BAB32664 AB071603 BAC16229 NM_053629 NP_446081
|
| Function |
The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000250}. Nucleus {ECO:0000250}.
|