Gene Symbol | ECs2715 |
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Entrez Gene | 912330 |
Alt Symbol | - |
Species | Escherichia coli |
Gene Type | protein-coding |
Description | EspF-like protein |
Other Description | - |
Swissprots | Q8X2D5 P0DJ88 P0DJ89 |
Accessions | BAB36138 NP_310742 |
Function | Required for efficient pedestal formation in host epithelial cells during infection. Acts as an intermediate between Tir (via host BAIAP2) and host WASL/N-WASP. Directly binds and activates WASL/N-WASP, which stimulates actin polymerization and leads to the formation of actin pedestals at the sites of bacterial adhesion. {ECO:0000269|PubMed:18650809, ECO:0000269|PubMed:22921828}. |
Subcellular Location | Secreted {ECO:0000250}. Host cytoplasm {ECO:0000250}. Note=Secreted via the type III secretion system (TTSS). In host cells, localizes to the tip of the actin pedestal (By similarity). {ECO:0000250}. |
Top Pathways | Pathogenic Escherichia coli infection |
Recombinant Secreted effector protein EspF(U) - CSB-YP320601EOD CSB-EP320601EOD CSB-BP320601EOD CSB-MP320601EOD from Cusabio
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Recombinant Secreted effector protein EspF(U) - CSB-YP319137EOD CSB-EP319137EOD CSB-BP319137EOD CSB-MP319137EOD from Cusabio
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Secreted effector protein EspF (U), Recombinant Protein - MBS1032790 from MyBioSource
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Secreted effector protein EspF (U), Recombinant Protein - MBS1123672 from MyBioSource
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