uvrB

Gene Symbol uvrB
Entrez Gene 7129123
Alt Symbol -
Species Escherichia coli
Gene Type protein-coding
Description excinuclease ABC subunit B
Other Description -
Swissprots B7MGN7
Accessions B7MGN7 CAR02135 YP_002390597
Function The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage. {ECO:0000255|HAMAP- Rule:MF_00204}.
Subcellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00204}.
Top Pathways Nucleotide excision repair

Recombinant Escherichia coli O45:K1 UvrABC system protein B(uvrB) - CSB-YP482655EOK CSB-EP482655EOK CSB-BP482655EOK CSB-MP482655EOK from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Escherichia coli

Recombinant Escherichia coli O45:K1 UvrABC system protein B(uvrB), Mammalian cell - CSB-MP482655EOK from Cusabio

Category Protein
Source Mammalian cell
Species Escherichia coli

Recombinant Escherichia coli O45:K1 UvrABC system protein B(uvrB), Baculovirus - CSB-BP482655EOK from Cusabio

Category Protein
Source Baculovirus
Species Escherichia coli

Recombinant Escherichia coli O45:K1 UvrABC system protein B(uvrB), Escherichia Coli - CSB-EP482655EOK from Cusabio

Category Protein
Source E.coli
Species Escherichia coli
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