Gene Symbol |
Cpb2
|
Entrez Gene |
56373
|
Alt Symbol |
1110032P04Rik, 4930405E17Rik, AI255929, CPR, Cpu, TAFI
|
Species |
Mouse
|
Gene Type |
protein-coding
|
Description |
carboxypeptidase B2 (plasma)
|
Other Description |
carboxypeptidase B2|carboxypeptidase R|carboxypeptidase U|thrombin-activable fibrinolysis inhibitor|thrombin-activatable fibrinolysis inhibitor
|
Swissprots |
Q9JHH6 Q9QZF0 Q5EBI3
|
Accessions |
ABU24468 EDL35833 Q9JHH6 AA048136 AB021968 BAB03402 AF164524 AAF62385 AF186188 AAF00528 AK004045 BAB23141 AK015095 BC089577 AAH89577 CO807338 NM_019775 NP_062749
|
Function |
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
|
Subcellular Location |
Secreted {ECO:0000269|PubMed:10739389}.
|
Tissue Specificity |
Plasma; synthesized in the liver. {ECO:0000269|PubMed:10739389}.
|
Top Pathways |
Complement and coagulation cascades, Protein digestion and absorption, Pancreatic secretion
|