LCN2

Gene Symbol LCN2
Entrez Gene 3934
Alt Symbol 24p3, MSFI, NGAL
Species Human
Gene Type protein-coding
Description lipocalin 2
Other Description 25 kDa alpha-2-microglobulin-related subunit of MMP-9|lipocalin-2|migration-stimulating factor inhibitor|neutrophil gelatinase-associated lipocalin|oncogene 24p3|p25|siderocalin LCN2
Swissprots B4DWV4 Q6FGL5 B7ZAA2 Q92683 Q5SYW0 P30150 P80188 A6NII8 Q5SYV9
Accessions CAA67574 EAW87748 EAW87749 EAW87750 P80188 AK301694 BAG63166 AK307311 AK316217 BAH14588 AW778875 BC033089 AAH33089 BF354583 BM977724 BP272828 BX644845 CA454137 CR542092 CAG46889 EU644752 ACD02429 N79823 S75256 AAD14168 X83006 CAA58127 NM_005564 NP_005555
Function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, i
Subcellular Location Secreted {ECO:0000269|PubMed:12453413}. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.
Tissue Specificity Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes. {ECO:0000269|PubMed:9339356}.

NGAL (C-14) - sc-18695 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NGAL (H-130) - sc-50350 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NGAL (H-130): sc-50350. Immunofluorescence staining of methanol-fixed HeLa cells showing cell surface localization.

NGAL (HYB 211-01) - sc-59622 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

NGAL (6B4) - sc-57518 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

NGAL (5G5) - sc-57517 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Anti-Lipocalin 2 antibody - ab63929 from Abcam

Prices $392.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab63929 staining Lipocalin 2 in the RAW264.7  cell line from Mouse macrophages by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde, permeabilized with Triton 0.1% + 2% BSA in PBS and blocked with 2% BSA for 30 minutes at 24°C. Samples were incubated with primary antibody (1/100 in PBS + 2% BSA) for 16 hours at 4°C. An Alexa Fluor®488-conjugated Goat anti-rabbit polyclonal(1/1000) was used as the secondary antibody.See Abreview

Anti-Lipocalin 2 antibody - ab41105 from Abcam

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Lipocalin 2 antibody (ab41105) at 1 µg/ml + Colon tissue lysate (Human) Tissue Lysate - adult normal tissue (ab30051) at 30 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Lipocalin 2 antibody - ab89819 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Lipocalin 2 antibody (ab89819) at 1 µg/ml + Human spleen tissue lysate at 50 µg

Anti-Lipocalin 2 antibody - ab31289 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-Lipocalin 2 antibody (ab31289) at 0.03 µg/ml + Human kidney lysate (35µg protein in RIPA buffer)

Anti-Lipocalin 2 antibody - ab115324 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Human Spleen (formalin-fixed, paraffin-embedded) stained with ab115324 at 2.5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Lipocalin 2 antibody - ab93963 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab93963, at 1/100 dilution, staining Lipocalin 2 in formalin-fixed, paraffin-embedded Human stomach adenocarcinoma tissue by Immunohistochemistry.

Anti-Lipocalin 2 antibody - ab166677 from Abcam

Host Sheep
Clonality Polyclonal

Anti-Lipocalin 2 antibody [23] - ab121053 from Abcam

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 23

Anti-Lipocalin 2 antibody [5G5] - ab23477 from Abcam

Prices $400.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5G5
ab23477 staining human skin tissue sections by IHC-P.  Sections were fixed in 10% neutral buffered formalin and subjected to heat mediated antigen retrieval prior to blocking with 1% BSA for 1 hour at 25°C.  The primary antibody was diluted 1/50 and incubated with the sample for 20 hours at 4°C.  A biotinylated horse anti-mouse antibody diluted 1/200 was used as the secondary.See Abreview

Anti-Lipocalin 2 antibody [EPR5084] - ab125075 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5084
All lanes : Anti-Lipocalin 2 antibody [EPR5084] (ab125075) at 1/1000 dilutionLane 1 : Human fetal kidney lysateLane 2 : SW480 cell lysateLysates/proteins at 10 µg per lane.

Anti-Lipocalin 2 antibody [MM0458-2G32] - ab89565 from Abcam

Prices $370.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Clone MM0458-2G32

Anti-LCN2 / Lipocalin 2 / NGAL Antibody (clone 5G5) - LS-C16216 from LifeSpan Bioscience

Prices $710.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5G5

Anti-LCN2 / Lipocalin 2 / NGAL Antibody - LS-C16217 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-LCN2 / Lipocalin 2 / NGAL Antibody (C-Terminus, Biotin) - LS-C37210 from LifeSpan Bioscience

Prices $755.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-LCN2 / Lipocalin 2 / NGAL Antibody (C-Terminus) - LS-C37208 from LifeSpan Bioscience

Prices $710.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-LCN2 / Lipocalin 2 / NGAL Antibody (C-Terminus) - LS-C37209 from LifeSpan Bioscience

Prices $710.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-LCN2 / Lipocalin 2 / NGAL Antibody (aa21-198) - LS-C37211 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-LCN2 / Lipocalin 2 / NGAL Antibody - LS-C71707 from LifeSpan Bioscience

Prices $710.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-LCN2 / Lipocalin 2 / NGAL Antibody - LS-C89458 from LifeSpan Bioscience

Prices $575.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-LCN2 / Lipocalin 2 / NGAL Antibody (clone 048-17) - LS-C89459 from LifeSpan Bioscience

Prices $590.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 048-17
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