ACLY

Gene Symbol	ACLY
Entrez Gene	47
Alt Symbol	ACL, ATPCL, CLATP
Species	Human
Gene Type	protein-coding
Description	ATP citrate lyase
Other Description	ATP citrate synthase\|ATP-citrate (pro-S-)-lyase\|ATP-citrate synthase\|citrate cleavage enzyme
Swissprots	Q9BRL0 B4DIM0 B4E3P0 P53396 Q13037
Accessions	EAW60777 EAW60778 EAW60779 EAW60780 EAW60781 P53396 AB210035 BAE06117 AK095084 BAC04484 AK295675 BAG58532 AK304802 BAG65552 AK312315 BC006195 AAH06195 BG037168 DB072009 DQ575356 JF432308 ADZ15525 U18197 AAB60340 X64330 CAA45614 XM_005257395 XP_005257452 NM_001096 NP_001087 NM_001303274 NP_001290203 NM_001303275 NP_001290204 NM_198830 NP_942127
Function	ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. {ECO:0000269\|PubMed:23932781}.
Subcellular Location	Cytoplasm.
Top Pathways	Citrate cycle (TCA cycle)

Phospho-ATP-Citrate Lyase (Ser455) Antibody - 4331 from Cell Signaling Technology

Prices	$109.00, $287.00
Sizes	20 µl (2 western blots), 100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from NIH/3T3 cells, untreated or PDGF-treated for the indicated times, using Phospho-ATP-Citrate Lyase (Ser455) Antibody (upper) or ATP-Citrate Lyase Antibody #4332 (lower).

ATP-Citrate Lyase Antibody - 4332 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from HeLa, NIH/3T3, C6 and COS cells, using ATP-Citrate Lyase Antibody.

ATP-Citrate Lyase (D1X6P) Rabbit mAb - 13390 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D1X6P

Western blot analysis of extracts from various cell lines using ATP-Citrate Lyase (D1X6P) Rabbit mAb.

ATP-citrate synthase (C-20) - sc-30538 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

ATP-citrate synthase (C-20): sc-30538. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

ATP-citrate synthase (G-17) - sc-30537 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

p-ATP-citrate synthase (A-12) - sc-374647 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

Western blot analysis of ATP-citrate synthase phosphorylation in untreated (A,D), calyculin A treated (B,E) and calyculin A and lambda protein phosphatase (sc-200312A) treated (C,F) Jurkat whole cell lysates. Antibodies tested include p-ATP-citrate synthase (A-12): sc-374647 (A,B,C) and ATP-citrate synthase (C-20): sc-30538 (D,E,F).

p-ATP-citrate synthase (Ser 455) - sc-33397 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

ATP-citrate synthase (H-240) - sc-368656 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Anti-ATP citrate lyase (phospho S455) antibody - ab59297 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Ab59297 at 1/50 dilution staining human colon carcinoma without (left) and with (right) immunizing peptide; paraffin embedded.

Anti-ATP citrate lyase (phospho S455) antibody [EP828Y] - ab46796 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP828Y

All lanes : Anti-ATP citrate lyase (phospho S455) antibody [EP828Y] (ab46796) at 1/5000 dilutionLane 1 : Untreated 3T3 cell lysatesLane 2 : Insulin treated 3T3 cell lysatesLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilutionObserved band size : 125 kDa (why is the actual band size different from the predicted?)

Anti-ATP citrate lyase (phospho T447 + S451) antibody [EP737Y] - ab53007 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP737Y

All lanes : Anti-ATP citrate lyase (phospho T447 + S451) antibody [EP737Y] (ab53007) at 1/1000 dilutionLane 1 : (A) 3T3 cell lysate (untreated cells)Lane 2 : (B) 3T3 cell lysate (insulin treated cells)Lysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP labelled at 1/2000 dilution

Anti-ATP citrate lyase antibody - ab61762 from Abcam

Prices	$384.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-ATP citrate lyase antibody (ab61762) at 1/500 dilutionLane 1 : Extracts from COS7 cells, treated with Calyculin (50nM, 30mins).Lane 2 : Extracts from COS7 cells, treated with Calyculin (50nM, 30mins) and the immunising peptide.

Anti-ATP citrate lyase antibody - ab126129 from Abcam

Prices	$376.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

ab126129, at 1/500 dilution, staining ATP citrate lyase in paraffin embedded Human hepatoma tissue by Immunohistochemistry.

Anti-ATP citrate lyase antibody [3G8] - ab118150 from Abcam

Prices	$384.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3G8

All lanes : Anti-ATP citrate lyase antibody [3G8] (ab118150) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY ATP citrate lyase cDNALysates/proteins at 5 µg per lane.

Anti-ATP citrate lyase antibody [5F8D11] - ab140664 from Abcam

Host	Mouse
Clonality	Monoclonal
Clone	5F8D11

Flow cytometric analysis of HeLa cells labeling ATP citrate lyase with ab140664 at 1/200 dilution (green; negative control (purple).

Anti-ATP citrate lyase antibody [EP704Y] - ab40793 from Abcam

Prices	$401.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP704Y

Anti-ATP citrate lyase antibody [EP704Y] (ab40793) at 1/5000 dilution + Hela cell lysate.

Anti-ATP citrate lyase antibody [none] - ab151270 from Abcam

Prices	$384.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	none

All lanes : Anti-ATP citrate lyase antibody [none] (ab151270) at 1/1000 dilutionLane 1 : K562 cell lysatesLane 2 : Hela cell lysates

Anti-ACLY / ATP Citrate Lyase Antibody (phospho-Ser455, clone EP828Y) - LS-C49785 from LifeSpan Bioscience

Prices	$450.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP828Y

Western blot analysis on 3T3 cell lysates using anti-Phospho-ACL (pS455) antibody, 1:5000 dilution. Cells were either (A) untreated (B) treated with insulin.

Anti-ACLY / ATP Citrate Lyase Antibody (aa420-469) - LS-C117739 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts from COS7 cells, treated with Calyculin 50 nM 30', using ATP-Citrate Lyase (Ab-454) Antibody. The lane on the right is treated with the synthesized peptide.

Anti-ACLY / ATP Citrate Lyase Antibody (C-Terminus, clone EP704Y) - LS-C49664 from LifeSpan Bioscience

Prices	$505.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP704Y

Western blot analysis on Hela cell lysate using anti-ATP citrate lyase antibody, dilution 1:5000.

Anti-ACLY / ATP Citrate Lyase Antibody - LS-C184984 from LifeSpan Bioscience

Prices	$395.00
Sizes	10 mg
Host	Rabbit
Clonality	Polyclonal

Anti-ACLY / ATP Citrate Lyase Antibody - LS-C184985 from LifeSpan Bioscience

Prices	$575.00
Sizes	1 mg
Host	Rabbit
Clonality	Polyclonal

Anti-ACLY / ATP Citrate Lyase Antibody (Biotin) - LS-C184986 from LifeSpan Bioscience

Prices	$475.00
Sizes	1 ml
Host	Rabbit
Clonality	Polyclonal

Anti-ACLY / ATP Citrate Lyase Antibody (aa575-624) - LS-C110718 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

ACLY / Citrate Lyase antibody LS-C110718 Western blot of ACHN lysate.

Anti-ACLY / ATP Citrate Lyase Antibody (aa451-500) - LS-C110717 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

ACLY / Citrate Lyase antibody LS-C110717 Western blot of ACHN lysate.

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