ACLY

Gene Symbol ACLY
Entrez Gene 47
Alt Symbol ACL, ATPCL, CLATP
Species Human
Gene Type protein-coding
Description ATP citrate lyase
Other Description ATP citrate synthase|ATP-citrate (pro-S-)-lyase|ATP-citrate synthase|citrate cleavage enzyme
Swissprots Q9BRL0 B4DIM0 B4E3P0 P53396 Q13037
Accessions EAW60777 EAW60778 EAW60779 EAW60780 EAW60781 P53396 AB210035 BAE06117 AK095084 BAC04484 AK295675 BAG58532 AK304802 BAG65552 AK312315 BC006195 AAH06195 BG037168 DB072009 DQ575356 JF432308 ADZ15525 U18197 AAB60340 X64330 CAA45614 XM_005257395 XP_005257452 NM_001096 NP_001087 NM_001303274 NP_001290203 NM_001303275 NP_001290204 NM_198830 NP_942127
Function ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. {ECO:0000269|PubMed:23932781}.
Subcellular Location Cytoplasm.
Top Pathways Citrate cycle (TCA cycle)