MADCAM1

Gene Symbol MADCAM1
Entrez Gene 8174
Alt Symbol MACAM1
Species Human
Gene Type protein-coding
Description mucosal vascular addressin cell adhesion molecule 1
Other Description MAdCAM-1|hMAdCAM-1|mucosal addressin cell adhesion molecule 1|mucosal addressin cell adhesion molecule-1
Swissprots Q5UGI7 A5PKV4 O60222 O75867 B2RPL9 Q13477
Accessions AAC51354 AAC62844 EAW61194 EAW61195 Q13477 AK092211 AY732484 AAV33123 AY819760 AAV68345 BC136408 AAI36409 BC137506 AAI37507 BC137507 AAI37508 BC142629 AAI42630 BC144065 AAI44066 DB323303 DQ076657 AAY82472 U43628 AAB02194 U82483 AAC13661 NM_130760 NP_570116 NM_130762 NP_570118
Function Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes. {ECO:0000269|PubMed:8609404, ECO:0000269|PubMed:8989586}.
Top Pathways Cell adhesion molecules (CAMs), Intestinal immune network for IgA production

MAdCAM-1 (H-3) - sc-365934 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MAdCAM-1 (H-3): sc-365934. Western blot analysis of MAdCAM-1 expression in Hep G2 (A) and ECV304 (B) whole cell lysates.

MAdCAM-1 (K-19) - sc-16004 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MAdCAM-1 (K-19): sc-16004. Western blot analysis of MAdCAM-1 expression in HeLa (A) and ECV304 (B) whole cell lysates.

MadCAM-1 (H-116) - sc-28645 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MAdCAM-1 (H-116): sc-28645. Western blot analysis of MAdCAM-1 expression in Hep G2 whole cell lysate.

MAdCAM-1 (MECA-367) - sc-19604 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
MAdCAM-1 (MECA-367): sc-19604. Western blot analysis of MAdCAM-1 expression in ECV304 whole cell lysate.

MAdCAM-1 (17F5) - sc-59790 from Santa Cruz Biotechnology

Host Mouse
Clonality Monoclonal

Anti-MAdCAM1 antibody - ab178549 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MAdCAM1 antibody (ab178549) at 0.5 µg/ml + HeLa cell lysate

Anti-MAdCAM1 antibody - ab198277 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MAdCAM1 antibody (ab198277) at 1/300 dilution + Mouse muscle tissue lysate at 40 µg

Anti-MAdCAM1 antibody - ab125397 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MAdCAM1 antibody (ab125397) at 1 µg/ml + MDA-MB-435S cell lysate at 10 µg with milk at 5 %

Anti-MAdCAM1 antibody [314G8] - ab34247 from Abcam

Prices $373.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 314G8

Anti-MAdCAM1 antibody [314G8] (Phycoerythrin) - ab58430 from Abcam

Prices $372.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone 314G8

Anti-MAdCAM1 antibody [EPR6946] - ab134088 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6946
All lanes : Anti-MAdCAM1 antibody [EPR6946] (ab134088) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : HUVEC cell lysateLane 3 : ECV-304 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti-rabbit at 1/2000 dilution

Anti-MAdCAM-1 Antibody (aa173-190) - LS-C313201 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
MADCAM1 / MAdCAM-1 antibody. IHC(F): Human Placenta Tissue.

Anti-MAdCAM-1 Antibody (clone MECA-367, Azide-free) - LS-C195683 from LifeSpan Bioscience

Prices $485.00
Sizes 500 µg
Host Rat
Clonality Monoclonal
Clone MECA-367

Anti-MAdCAM-1 Antibody (clone MECA-367) - LS-C195684 from LifeSpan Bioscience

Prices $435.00
Sizes 500 µg
Host Rat
Clonality Monoclonal
Clone MECA-367

Anti-MAdCAM-1 Antibody (clone MECA-367, Biotin) - LS-C196516 from LifeSpan Bioscience

Prices $465.00
Sizes 500 µg
Host Rat
Clonality Monoclonal
Clone MECA-367

Anti-MAdCAM-1 Antibody (clone MECA-367, FITC) - LS-C196517 from LifeSpan Bioscience

Prices $485.00
Sizes 500 µg
Host Rat
Clonality Monoclonal
Clone MECA-367

Anti-MAdCAM-1 Antibody (aa29-297, Biotin) - LS-C297192 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAdCAM-1 Antibody (clone 314G8, FITC) - LS-C210274 from LifeSpan Bioscience

Prices $665.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 314G8

Anti-MAdCAM-1 Antibody (Extracellular Domain, clone EPR6946) - LS-C152297 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6946
Western blot analysis on (A) HeLa, (B) HUVEC, and (C) ECV-304 cell lysates using anti-MADCAM1 antibody.

Anti-MAdCAM-1 Antibody (aa29-297, FITC) - LS-C304047 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAdCAM-1 Antibody (aa235-284) - LS-C146484 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MADCAM1 / MAdCAM-1 antibody LS-C146484 Western blot of 435S Cell lysate. Antibody concentration 1 ug/ml.

Anti-MAdCAM-1 Antibody (aa29-297) - LS-C295461 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant MADCAM1 / MAdCAM-1.

Anti-MAdCAM-1 Antibody (clone 2B1) - LS-C338268 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B1
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MADCAM1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MADCAM1.

Anti-MAdCAM-1 Antibody (clone 1E5) - LS-C338271 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MADCAM1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MADCAM1.

Anti-MAdCAM-1 Antibody (clone 1D6) - LS-C338270 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D6
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MADCAM1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MADCAM1.
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