YWHAB

Gene Symbol	YWHAB
Entrez Gene	7529
Alt Symbol	GW128, HEL-S-1, HS1, KCIP-1, YWHAA
Species	Human
Gene Type	protein-coding
Description	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Other Description	14-3-3 alpha|14-3-3 protein beta/alpha|brain protein 14-3-3, beta isoform|epididymis secretory protein Li 1|protein 1054|protein kinase C inhibitor protein 1|protein kinase C inhibitor protein-1|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide|tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Swissprots	E1P616 A8K9K2 P31946
Accessions	EAW75893 EAW75894 EAW75895 EAW75896 P31946 AA845374 AB209759 BAD92996 AB451260 BAG70074 AB451386 BAG70200 AF064847 AF107406 AAD44524 AK292717 BAF85406 AL834170 BC001359 AAH01359 BC010352 BF316820 DB443535 EU794580 ACJ13634 EU832334 ACE87591 EU832419 ACE86904 X57346 CAA40621 NM_003404 NP_003395 NM_139323 NP_647539
Function	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Top Pathways	Cell cycle, Oocyte meiosis, Viral carcinogenesis, PI3K-Akt signaling pathway, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

14-3-3 β siRNA (h) - sc-29186 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

14-3-3 β shRNA Plasmid (h) - sc-29186-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

14-3-3 β shRNA (h) Lentiviral Particles - sc-29186-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

14-3-3 beta/alpha RNAi - H00007529-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

14-3-3 beta/alpha RNAi - H00007529-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU091811 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN23030 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23030 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

YWHAB siRNA (Human) - CRH5143 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

YWHAB - MBS828756 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human YWHAB (NM_003404.3) - SHH448664 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human YWHAB(NM_003404.3) - SHL132552 from Creative biogene Category siRNA Species Reactivities Human

YWHAB shRNA Plasmid (Human) - CHH5143 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

YWHAB miRNA 3'UTR clone - MiUTR1H-11348 from Creative biogene Species Reactivities Human

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