Gene Symbol | Oxct1 |
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Entrez Gene | 67041 |
Alt Symbol | 2610008O03Rik, Oxct, Oxct2a, Scot-s |
Species | Mouse |
Gene Type | protein-coding |
Description | 3-oxoacid CoA transferase 1 |
Other Description | 3-oxoacid CoA-transferase 1|3-oxoacid-CoA transferase 1|somatic-type succinyl CoA:3-oxoacid CoA-transferase|somatic-type succinyl-CoA:3-oxoacid CoA-transferase|succinyl-CoA:3-ketoacid CoA transferase|succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial|succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial |
Swissprots | Q3TIW6 Q9D0K2 Q9CV92 |
Accessions | EDL03395 Q9D0K2 AB085609 BAC05524 AK009027 BAB26035 AK010029 AK010790 BAB27184 AK011354 BAB27562 AK078086 AK146158 BAE26941 AK146342 BAE27096 AK151662 BAE30590 AK151695 BAE30619 AK154327 AK167681 BAE39730 AK178525 AK181182 AK181314 AK184597 AK185295 AK185909 AK204528 AK209412 AK209817 AK209998 AK215681 AK217531 BC003422 AAH03422 BE952161 EF095212 ABL01516 NM_024188 NP_077150 |
Function | Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). {ECO:0000250}. |
Subcellular Location | Mitochondrion matrix {ECO:0000250}. |
Top Pathways | Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism |
SCOT CRISPR/Cas9 KO Plasmid (m) - sc-426343 from Santa Cruz Biotechnology
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SCOT HDR Plasmid (m) - sc-426343-HDR from Santa Cruz Biotechnology
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SCOT Double Nickase Plasmid (m) - sc-426343-NIC from Santa Cruz Biotechnology
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SCOT Double Nickase Plasmid (m2) - sc-426343-NIC-2 from Santa Cruz Biotechnology
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SCOT CRISPR Activation Plasmid (m) - sc-426343-ACT from Santa Cruz Biotechnology
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SCOT CRISPR Activation Plasmid (m2) - sc-426343-ACT-2 from Santa Cruz Biotechnology
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SCOT Lentiviral Activation Particles (m) - sc-426343-LAC from Santa Cruz Biotechnology
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SCOT Lentiviral Activation Particles (m2) - sc-426343-LAC-2 from Santa Cruz Biotechnology
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SCOT siRNA (m) - sc-153266 from Santa Cruz Biotechnology
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SCOT shRNA Plasmid (m) - sc-153266-SH from Santa Cruz Biotechnology
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SCOT shRNA (m) Lentiviral Particles - sc-153266-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU030301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN38145 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38145 from Sigma-Aldrich
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OXCT1 siRNA (Mouse) - CRM6962 from Cohesion Biosciences
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shRNA set against Mouse OXCT1 (NM_024188.6) - SHH369304 from Creative biogene
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shRNA set against Mouse Oxct1(NM_024188.6) - SHR084156 from Creative biogene
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OXCT1 shRNA Plasmid (Mouse) - CHM6962 from Cohesion Biosciences
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OXCT1 miRNA 3'UTR clone - MiUTR1M-08827 from Creative biogene
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