DTX1

Gene Symbol	DTX1
Entrez Gene	1840
Alt Symbol	hDx-1
Species	Human
Gene Type	protein-coding
Description	deltex 1, E3 ubiquitin ligase
Other Description	E3 ubiquitin-protein ligase DTX1|deltex homolog 1|deltex1|hDTX1|protein deltex-1
Swissprots	O60630 Q86Y01 Q9BS04
Accessions	EAW98028 EAW98029 Q86Y01 AF053700 AAC06246 BC005816 AAH05816 BC008321 BC048216 AAH48216 XM_011538009 XP_011536311 NM_004416 NP_004407
Function	Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T- cell development, suggesting that it can antagonize NOTCH1. {ECO:0000250, ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:11869684, ECO:0000269|PubMed:9590294}.
Subcellular Location	Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
Tissue Specificity	Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells. {ECO:0000269|PubMed:12753744, ECO:0000269|PubMed:9590294}.
Top Pathways	Notch signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Deltex full length protein - ab158326 from Abcam Category Protein Source Wheat germ Species Human

Human Deltex protein fragment - ab158327 from Abcam Category Protein Source Wheat germ Species Human

DTX1 / Deltex Antibody Blocking Peptide - LS-E27208 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DTX1 / Deltex Antibody Blocking Peptide - LS-E13821 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DTX1 / Deltex Antibody Blocking Peptide - LS-E9855 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DTX1 Protein - H00001840-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human DTX1 Protein - H00001840-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DTX1-Antibody-Center-Blocking-Peptide - BP13133c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DTX1-Antibody-Center-Blocking-Peptide - BP8923c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Deltex1 blocking peptide - GTX88253-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

DTX1 Immunizing peptide - orb17112 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Deltex-1 peptide - orb72607 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

DTX1 Peptide - AC21-2029-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Deltex-1 / DTX1 - H00001840-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Deltex-1 / DTX1 - H00001840-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Deltex-1 / DTX1 - H00001840-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DTX1 Peptide - 42-248P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

DTX1 fusion protein - ag13148 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

DTX1 fusion protein - ag13172 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Deltex Homolog 1 (DTX1) - RPL451Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Deltex Homolog 1 (DTX1) - RPL451Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Protein deltex-1(DTX1) - CSB-YP773055HU CSB-EP773055HU CSB-BP773055HU CSB-MP773055HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Deltex Homolog 1 Protein (Recombinant) - abx168143 from Abbexa Category Protein Source Human Species Human

DTX1/Deltex-1, Peptide - MBS426457 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

DTX1 Protein - NBP2-13940PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

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