ATP5F1

Gene Symbol ATP5F1
Entrez Gene 515
Alt Symbol PIG47
Species Human
Gene Type protein-coding
Description ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
Other Description ATP synthase B chain, mitochondrial|ATP synthase F(0) complex subunit B1, mitochondrial|ATP synthase proton-transporting mitochondrial F(0) complex subunit B1|ATP synthase subunit b, mitochondrial|ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1|ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b|ATPase subunit b|H+-ATP synthase subunit b|cell proliferation-inducing protein 47
Swissprots P24539 Q9BRU8 Q9BQ68
Accessions EAW56495 EAW56496 P24539 AI754631 AK223018 BAD96738 AK291077 BAF83766 AK308266 AK311287 AK313541 BAG36318 AW385236 AW778751 AY871272 AAX11428 BC005366 AAH05366 BC005960 AAH05960 BC016350 AAH16350 BF237506 D28383 BAA05749 X60221 CAA42782 NM_001688 NP_001679
Function Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Subcellular Location Mitochondrion. Mitochondrion inner membrane.
Top Pathways Alzheimer's disease, Huntington's disease, Oxidative phosphorylation