ATP5F1
| Gene Symbol | ATP5F1 |
|---|---|
| Entrez Gene | 515 |
| Alt Symbol | PIG47 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 |
| Other Description | ATP synthase B chain, mitochondrial|ATP synthase F(0) complex subunit B1, mitochondrial|ATP synthase proton-transporting mitochondrial F(0) complex subunit B1|ATP synthase subunit b, mitochondrial|ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1|ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b|ATPase subunit b|H+-ATP synthase subunit b|cell proliferation-inducing protein 47 |
| Swissprots | P24539 Q9BRU8 Q9BQ68 |
| Accessions | EAW56495 EAW56496 P24539 AI754631 AK223018 BAD96738 AK291077 BAF83766 AK308266 AK311287 AK313541 BAG36318 AW385236 AW778751 AY871272 AAX11428 BC005366 AAH05366 BC005960 AAH05960 BC016350 AAH16350 BF237506 D28383 BAA05749 X60221 CAA42782 NM_001688 NP_001679 |
| Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. |
| Subcellular Location | Mitochondrion. Mitochondrion inner membrane. |
| Top Pathways | Alzheimer's disease, Huntington's disease, Oxidative phosphorylation |
ATP5F1 CRISPR/Cas9 KO Plasmid (h) - sc-405710 from Santa Cruz Biotechnology
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ATP5F1 HDR Plasmid (h) - sc-405710-HDR from Santa Cruz Biotechnology
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ATP5F1 Double Nickase Plasmid (h) - sc-405710-NIC from Santa Cruz Biotechnology
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ATP5F1 Double Nickase Plasmid (h2) - sc-405710-NIC-2 from Santa Cruz Biotechnology
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ATP5F1 CRISPR Activation Plasmid (h) - sc-405710-ACT from Santa Cruz Biotechnology
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ATP5F1 CRISPR Activation Plasmid (h2) - sc-405710-ACT-2 from Santa Cruz Biotechnology
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ATP5F1 Lentiviral Activation Particles (h) - sc-405710-LAC from Santa Cruz Biotechnology
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ATP5F1 Lentiviral Activation Particles (h2) - sc-405710-LAC-2 from Santa Cruz Biotechnology
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ATP5F1 siRNA (h) - sc-88835 from Santa Cruz Biotechnology
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ATP5F1 shRNA Plasmid (h) - sc-88835-SH from Santa Cruz Biotechnology
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ATP5F1 shRNA (h) Lentiviral Particles - sc-88835-V from Santa Cruz Biotechnology
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ATP5F1 RNAi - H00000515-R02 from Novus Biologicals
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ATP5F1 RNAi - H00000515-R01 from Novus Biologicals
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ATP5F1 RNAi - H00000515-R03 from Novus Biologicals
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MISSION® esiRNA - EHU108051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3700 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3700 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06762 from Sigma-Aldrich
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ATP5F1 siRNA (Human) - CRH0356 from Cohesion Biosciences
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ATP5F1 - MBS8205562 from MyBioSource
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shRNA set against Human ATP5F1 (NM_001688.4) - SHH242794 from Creative biogene
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shRNA set against Human ATP5F1(NM_001688.4) - SHG082303 from Creative biogene
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ATP5F1 shRNA Plasmid (Human) - CHH0356 from Cohesion Biosciences
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ATP5F1 miRNA 3'UTR clone - MiUTR1H-00695 from Creative biogene
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