| Gene Symbol |
Ccrn4l
|
| Entrez Gene |
310395
|
| Alt Symbol |
Ccr4, Ccrn4lb
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
CCR4 carbon catabolite repression 4-like (S. cerevisiae)
|
| Other Description |
CCR4 carbon catabolite repression 4-like B|CCR4 protein homolog|carbon catabolite epression 4 homolog|carbon catabolite repression 4-like protein|circadian deadenylase NOC|nocturin|nocturnin
|
| Swissprots |
Q9ET55 G3V7F4
|
| Accessions |
EDM15000 Q9ET55 AF199495 AAG01390 NM_138526 NP_612535
|
| Function |
Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase- independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.
|
