| Gene Symbol |
Arid3a
|
| Entrez Gene |
13496
|
| Alt Symbol |
Bright, Dri1, Dril1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
AT rich interactive domain 3A (BRIGHT-like)
|
| Other Description |
ARID domain-containing protein 3A|AT rich interactive domain 3A (Bright like)|AT-rich interactive domain-containing protein 3A|B-cell regulator of IgH transcription|dead ringer homolog 1|dead ringer-like protein 1
|
| Swissprots |
Q80YP8 Q62431 Q3U338
|
| Accessions |
EDL31622 EDL31623 EDL31624 Q62431 AK034824 AK141283 BAE24635 AK154956 BAE32951 AK155569 BC050925 AAH50925 BP763961 BY126533 U60335 AAB03416 XM_006513201 XP_006513264 XM_006513202 XP_006513265 XM_011243364 XP_011241666 NM_001288625 NP_001275554 NM_001288626 NP_001275555 NM_007880 NP_031906
|
| Function |
Transcription factor involved in B-cell differentiation. Binds a VH promoter proximal site necessary for induced mu-heavy- chain transcription. Binds the minor groove of a restricted ATC sequence that is sufficient for nuclear matrix association. This sequence motif is present in matrix-associating regions (MARS) proximal to the promoter and flanking E mu. Activates E mu-driven transcription by binding these sites. May be involved in the control of cell cycle progression by the RB1/E2F1 pathway. {ECO:0000269|PubMed:11294836, ECO:0000269|PubMed:17312145, ECO:0000269|PubMed:8543152}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm.
|
| Tissue Specificity |
B-cell specific in the adult. Expressed in B- cell progenitors, down-regulated in the immature B-cell stage, and is up-regulated again at later stages of B-lymphocyte differentiation. {ECO:0000269|PubMed:9590220}.
|