| Gene Symbol | Ppp1r9b |
|---|---|
| Entrez Gene | 217124 |
| Alt Symbol | SPL, Spn |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | protein phosphatase 1, regulatory subunit 9B |
| Other Description | neurabin II|neurabin-2|neurabin-II|spinophilin |
| Swissprots | Q8K0X7 Q6R891 |
| Accessions | Q6R891 AI841686 AK084730 BAC39266 AY508450 AAR91608 BC029672 AAH29672 BC169325 BC169326 NM_172261 NP_758465 |
| Function | Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha- adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse. Cell junction, adherens junction {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Enriched at synapse and cadherin- based cell-cell adhesion sites. In neurons, both cytosolic and membrane-associated, and highly enriched in the postsynaptic density apposed to exitatory synapses. Colocalizes with PPP1R2 at actin-rich adherens junctions in epithelial cells and in dendritic spines. Accumulates in the lamellipodium, filopodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (By similarity). {ECO:0000250}. |
Neurabin-II CRISPR/Cas9 KO Plasmid (m) - sc-432169 from Santa Cruz Biotechnology
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Neurabin-II HDR Plasmid (m) - sc-432169-HDR from Santa Cruz Biotechnology
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Neurabin-II Double Nickase Plasmid (m) - sc-432169-NIC from Santa Cruz Biotechnology
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Neurabin-II Double Nickase Plasmid (m2) - sc-432169-NIC-2 from Santa Cruz Biotechnology
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Neurabin-II CRISPR Activation Plasmid (m) - sc-432169-ACT from Santa Cruz Biotechnology
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Neurabin-II CRISPR Activation Plasmid (m2) - sc-432169-ACT-2 from Santa Cruz Biotechnology
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Neurabin-II Lentiviral Activation Particles (m) - sc-432169-LAC from Santa Cruz Biotechnology
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Neurabin-II Lentiviral Activation Particles (m2) - sc-432169-LAC-2 from Santa Cruz Biotechnology
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Neurabin-II siRNA (m) - sc-149924 from Santa Cruz Biotechnology
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Neurabin-II shRNA Plasmid (m) - sc-149924-SH from Santa Cruz Biotechnology
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Neurabin-II shRNA (m) Lentiviral Particles - sc-149924-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU048131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN39187 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND39187 from Sigma-Aldrich
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PPP1R9B siRNA (Mouse) - CRN2106 from Cohesion Biosciences
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shRNA set against Mouse Ppp1r9b (NM_172261.3) - SHH381328 from Creative biogene
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PPP1R9B shRNA Plasmid (Mouse) - CHN2106 from Cohesion Biosciences
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