| Gene Symbol |
Hpse
|
| Entrez Gene |
15442
|
| Alt Symbol |
HSE1, Hpa, Hpr1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
heparanase
|
| Other Description |
endo-glucoronidase|endoglycosidase heparanase
|
| Swissprots |
B2RS99 Q8K3K3 Q6YGZ1
|
| Accessions |
ABG57024 EDL20281 EDL20282 EDL20283 Q6YGZ1 AF359507 AAQ15188 AK040471 BAC30600 AK087283 AK154628 BAE32725 AK190307 AK197417 AK197785 AK200041 AY077467 AAL76083 AY151051 AAN41636 BC099521 BC138782 AAI38783 BC138784 AAI38785 NM_152803 NP_690016
|
| Function |
Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation fa
|
| Subcellular Location |
Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000269|PubMed:15793281}. Nucleus {ECO:0000269|PubMed:15793281}. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity). Associates with lipid rafts. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in skin, mainly in the stratum granulosum and the first layer of the stratum corneum in the upper part of the epidermis. Also detected in hair follicles and in sebaceous glands. {ECO:0000269|PubMed:15793281, ECO:0000269|PubMed:18589009}.
|
| Top Pathways |
Proteoglycans in cancer, Glycosaminoglycan degradation
|