| Gene Symbol |
WAPAL
|
| Entrez Gene |
23063
|
| Alt Symbol |
FOE, KIAA0261, WAPL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
wings apart-like homolog (Drosophila)
|
| Other Description |
friend of EBNA2 (Epstein-Barr virus nuclear protein 2)|friend of EBNA2 protein|wings apart-like protein homolog
|
| Swissprots |
Q92549 Q5VSK5 A7E2B5 Q7Z5K2 Q8IX10
|
| Accessions |
EAW80334 EAW80335 EAW80336 EAW80337 Q7Z5K2 AB065003 BAC78631 AB426821 BAG55435 AB426822 BAG55436 AB426823 BAG55437 AB426824 BAG55438 AB426825 BAG55439 AB426826 BAG55440 AB426827 BAG55441 AB426828 BAG55442 AB426829 BAG55443 AB426830 BAG55444 AB426831 BAG55445 AB426832 BAG55446 AB426833 BAG55447 AB426834 BAG55448 AB426835 BAG55449 AB426836 BAG55450 AB426837 BAG55451 AB426838 BAG55452 AF479418 AAO14651 AK000849 AK027005 AK290138 BAF82827 BC017393 AAH17393 BC036507 BC105991 BC140858 AAI40859 BC150269 AAI50270 D87450 BAA13391 XM_006717729 XP_006717792 XM_011539547 XP_011537849 XM_011539548 XP_011537850 NM_015045 NP_055860
|
| Function |
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister- chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:17112726, ECO:0000269|PubMed:17113138, ECO:0000269|PubMed:19696148, ECO:0000269|PubMed:19907496, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:23776203}.
|
| Subcellular Location |
Isoform 2: Nucleus.
|
| Tissue Specificity |
Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:15383329}.
|
