| Gene Symbol |
ITCH
|
| Entrez Gene |
83737
|
| Alt Symbol |
ADMFD, AIF4, AIP4, NAPP1, dJ468O1.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
itchy E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase Itchy homolog|NFE2-associated polypeptide 1|atrophin-1 interacting protein 4|dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))|itchy E3 ubiquitin protein ligase homolog
|
| Swissprots |
Q9H4U5 E1P5P3 F5H217 Q9BY75 B4E234 Q9H451 Q96F66 Q5TEL0 Q5QP37 A6NEW4 Q96J02 O43584
|
| Accessions |
EAW76272 EAW76273 EAW76274 EAW76275 EAW76276 EAW76277 EAW76278 Q96J02 AA730741 AB056663 BAB39389 AB209747 BAD92984 AF038564 AAC04845 AF095745 AAK39399 AK297809 BAG60147 AK304090 BAG64996 AK315212 BAG37647 AL705688 BC006848 AAH06848 BC011571 AAH11571 DC307047 XM_005260570 XP_005260627 XM_011529077 XP_011527379 XM_011529078 XP_011527380 XM_011529079 XP_011527381 XR_244153 NM_001257137 NP_001244066 NM_001257138 NP_001244067 NM_031483 NP_113671
|
| Function |
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1. Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways. Regulates the transcriptional ac
|
| Subcellular Location |
Cell membrane. Cytoplasm {ECO:0000250}. Nucleus. Note=Associates with endocytic vesicles. May be recruited to exosomes by NDFIP1.
|
| Tissue Specificity |
Widely expressed.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Endocytosis, TNF signaling pathway, Non-alcoholic fatty liver disease (NAFLD)
|