GAL3ST1

Gene Symbol GAL3ST1
Entrez Gene 9514
Alt Symbol CST
Species Human
Gene Type protein-coding
Description galactose-3-O-sulfotransferase 1
Other Description 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase|3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase|GalCer sulfotransferase|cerebroside (3'-phosphoadenylylsulfate:galactosylceramide 3') sulfotransferase|cerebroside sulfotransferase|galactosylceramide sulfotransferase
Swissprots Q96C63 Q99999
Accessions BAA89503 EAW59899 EAW59900 EAW59901 EAW59902 EAW59903 Q99999 AK313097 BAG35921 BC014649 AAH14649 BC019077 AAH19077 CR456350 CAG30236 CU013060 CAK54491 CU013348 CAK54790 D88667 BAA13673 DQ892272 ABM83198 DQ895473 ABM86399 XM_005261848 XP_005261905 XM_005261853 XP_005261910 XM_005261856 XP_005261913 XM_011530518 XP_011528820 XM_011530519 XP_011528821 XM_011530520 XP_011528822 XM_011530521 XP_011528823 XM_011530522 XP_011528824 XM_011530523 XP_011528825 XM_011530524 XP_011528826 XM_011530525 XP_011528827 XM_011530526 XP_011528828 XM_011530527 XP_011528829 XM_011530528 XP_011528830 XM_011530529 XP_011528831 XM_011530530 XP_011528832 XM_011530531 XP_011528833 XM_011530532 XP_011528834 XM_011530533 XP_011528835 XM_011530534 XP_011528836 XM_011530535 XP_011528837 XM_011530536 XP_011528838 NM_004861 NP_004852
Function Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). {ECO:0000250, ECO:0000269|PubMed:8830034}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Expressed in kidney proximal tubule, gastric mucosa and adenocarcinoma. Highly expressed in renal cell carcinoma cell lines.
Top Pathways Ether lipid metabolism, Sphingolipid metabolism