| Gene Symbol |
GAL3ST1
|
| Entrez Gene |
9514
|
| Alt Symbol |
CST
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
galactose-3-O-sulfotransferase 1
|
| Other Description |
3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase|3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase|GalCer sulfotransferase|cerebroside (3'-phosphoadenylylsulfate:galactosylceramide 3') sulfotransferase|cerebroside sulfotransferase|galactosylceramide sulfotransferase
|
| Swissprots |
Q96C63 Q99999
|
| Accessions |
BAA89503 EAW59899 EAW59900 EAW59901 EAW59902 EAW59903 Q99999 AK313097 BAG35921 BC014649 AAH14649 BC019077 AAH19077 CR456350 CAG30236 CU013060 CAK54491 CU013348 CAK54790 D88667 BAA13673 DQ892272 ABM83198 DQ895473 ABM86399 XM_005261848 XP_005261905 XM_005261853 XP_005261910 XM_005261856 XP_005261913 XM_011530518 XP_011528820 XM_011530519 XP_011528821 XM_011530520 XP_011528822 XM_011530521 XP_011528823 XM_011530522 XP_011528824 XM_011530523 XP_011528825 XM_011530524 XP_011528826 XM_011530525 XP_011528827 XM_011530526 XP_011528828 XM_011530527 XP_011528829 XM_011530528 XP_011528830 XM_011530529 XP_011528831 XM_011530530 XP_011528832 XM_011530531 XP_011528833 XM_011530532 XP_011528834 XM_011530533 XP_011528835 XM_011530534 XP_011528836 XM_011530535 XP_011528837 XM_011530536 XP_011528838 NM_004861 NP_004852
|
| Function |
Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). {ECO:0000250, ECO:0000269|PubMed:8830034}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed in kidney proximal tubule, gastric mucosa and adenocarcinoma. Highly expressed in renal cell carcinoma cell lines.
|
| Top Pathways |
Ether lipid metabolism, Sphingolipid metabolism
|