TAF4B

Gene Symbol TAF4B
Entrez Gene 6875
Alt Symbol SPGF13, TAF2C2, TAFII105
Species Human
Gene Type protein-coding
Description TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
Other Description TAF(II)105|TATA box binding protein (TBP)-associated factor 4B|TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD|transcription initiation factor TFIID 105 kDa subunit|transcription initiation factor TFIID subunit 4B
Swissprots Q29YA5 Q29YA4 Q92750
Accessions BAF51562 CCO13829 EAX01217 EAX01218 Q92750 AB234096 BAF51561 AK302593 BAG63845 AY888048 AAX14897 AY888049 AAX14898 BC016360 BC032791 BC169304 BC169305 Y09321 CAA70499 XM_005258339 XP_005258396 XM_006722528 XP_006722591 XM_011526153 XP_011524455 NM_001293725 NP_001280654 NM_005640 NP_005631 NR_121653
Function Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. {ECO:0000250|UniProtKB:G5E8Z2, ECO:0000269|PubMed:10828057, ECO:0000269|PubMed:10849440, ECO:0000269|PubMed:16088961, ECO:0000303|PubMed:24431330}.
Subcellular Location Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.
Tissue Specificity Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells. {ECO:0000269|PubMed:16088961, ECO:0000269|PubMed:8858156}.
Top Pathways Huntington's disease, Herpes simplex infection, Basal transcription factors

human TAF4B ORF clone (NM_005640.1) - CDCH088574 from Creative biogene

Species Human

Human TAF4B cDNA Clone(NM_005640.1) - CDFH019176 from Creative biogene

Species Human
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