DDR1
| Gene Symbol | DDR1 |
|---|---|
| Entrez Gene | 780 |
| Alt Symbol | CAK, CD167, DDR, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE |
| Species | Human |
| Gene Type | protein-coding |
| Description | discoidin domain receptor tyrosine kinase 1 |
| Other Description | CD167 antigen-like family member A|PTK3A protein tyrosine kinase 3A|cell adhesion kinase|epithelial discoidin domain-containing receptor 1|mammary carcinoma kinase 10|neuroepithelial tyrosine kinase|neurotrophic tyrosine kinase, receptor, type 4|protein-tyrosine kinase RTK-6|tyrosine kinase DDR|tyrosine-protein kinase CAK |
| Swissprots | B5A976 Q4LE50 Q16562 Q2L6H3 Q9UD36 Q5ST11 Q5ST12 Q6NSK4 Q08345 Q14196 B5A975 Q9UD35 Q9UDL2 Q9UD37 Q9UD86 B7Z2K0 |
| Accessions | AAC50917 BAB63318 BAC54935 BAE78621 BAF31270 CAA66871 EAX03335 EAX03336 EAX03337 EAX03338 EAX03339 EAX03340 EAX03341 EAX03342 EAX03343 EAX03344 EAX03345 EAX03346 Q08345 AB210021 BAE06103 AF353182 AAK48842 AF353183 AAK48843 AK130776 BAC85426 AK291621 BAF84310 AK294793 BAH11886 AK295643 BAH12138 BC008716 AAH08716 BC013400 AAH13400 BC070070 AAH70070 BI193181 BM875592 CN362335 DA461082 DC369107 EU826613 ACF47649 EU826614 ACF47650 L11315 AAA02866 L20817 AAA18019 L57508 AAB05208 X74979 CAA52915 Z29093 CAA82335 XM_006715185 XP_006715248 XM_006725501 XP_006725564 XM_006725827 XP_006725890 XM_006726017 XP_006726080 XM_011514882 XP_011513184 XM_011514883 XP_011513185 XM_011514884 XP_011513186 XM_011514885 XP_011513187 XM_011514886 XP_011513188 XM_011514887 XP_011513189 XM_011514888 XP_011513190 XM_011547282 XP_011545584 XM_011547283 XP_011545585 XM_011547284 XP_011545586 XM_011547285 XP_011545587 XM_011547286 XP_011545588 XM_011547287 XP_011545589 XM_011547288 XP_011545590 XM_011547683 XP_011545985 XM_011547684 XP_011545986 XM_011547685 XP_011545987 XM_011547686 XP_011545988 XM_011547687 XP_011545989 XM_011547688 XP_011545990 XM_011547689 XP_011545991 XM_011547902 XP_011546204 XM_011547903 XP_011546205 XM_011547904 XP_011546206 XM_011547905 XP_011546207 XM_011547906 XP_011546208 XM_011547907 XP_011546209 XM_011547908 XP_011546210 XM_011548268 XP_011546570 XM_011548269 XP_011546571 XM_011548270 XP_011546572 XM_011548271 XP_011546573 XM_011548272 XP_011546574 XM_011548273 XP_011546575 XM_011548274 XP_011546576 NM_001202521 NP_001189450 NM_001202522 NP_001189451 NM_001202523 NP_001189452 NM_001297652 NP_001284581 NM_001297653 NP_001284582 NM_001297654 NP_001284583 NM_001954 NP_001945 NM_013993 NP_054699 NM_013994 NP_054700 |
| Function | Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. {ECO:0000250, ECO:0000269|PubMed:12065315, ECO:0000269|PubMed:16234985, ECO:0000269|PubMed:16337946, ECO:0000269|PubMed |
| Subcellular Location | Isoform 3: Secreted {ECO:0000305}. |
| Tissue Specificity | Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin. {ECO:0000269|PubMed:7845687, ECO:0000269|PubMed:7848919, ECO:0000269|PubMed:8247543}. |
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