ACVR1B

Gene Symbol ACVR1B
Entrez Gene 91
Alt Symbol ACTRIB, ACVRLK4, ALK4, SKR2
Species Human
Gene Type protein-coding
Description activin A receptor, type IB
Other Description activin A receptor, type II-like kinase 4|activin receptor type-1B|activin receptor-like kinase 4|serine/threonine-protein kinase receptor R2
Swissprots Q15481 B7Z5W5 B7Z5L8 Q15480 P36896 Q15482 Q15479
Accessions AAA53349 AAA53350 AAA53351 EAW58216 EAW58217 EAW58218 P36896 AK299120 BAH12954 AK299496 BAH13051 AL117643 BC000254 AAH00254 BC034008 BC040531 AAH40531 BT007072 AAP35735 EU831986 ACE87427 EU832079 ACE86741 L10125 AAA60555 L10126 AAA60556 U14722 AAA50246 Z22536 CAA80258 XM_011538966 XP_011537268 XM_011538967 XP_011537269 NM_004302 NP_004293 NM_020327 NP_064732 NM_020328 NP_064733
Function Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine- threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as AC
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
Top Pathways Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells

ACTR-IB (A-15) - sc-31298 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACTR-IB (A-15): sc-31298. Western blot analysis of ACTR-IB expression in Hep G2 whole cell lysate.

ACTR-IB (H-75) - sc-25450 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ACTR-IB (I-15) - sc-31297 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACTR-IB (I-15): sc-31297. Western blot analysis of ACTR-IB expression in mouse brain tissue extract.

ACTR-IB (N-20) - sc-11984 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACTR-IB (N-20): sc-11984. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of exocrine glandular cells and Islets of Langerhans.

ACTR-IB (T-17) - sc-11986 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACTR-IB (T-17): sc-11986. Western blot analysis of ACTR-IB expression in HeLa whole cell lysate.

ACTR-IB (ALEX66) - sc-73677 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
ACTR-IB (ALEX66): sc-73677. Western blot analysis of ACTR-IB expression in mouse brain tissue extract.

Anti-Activin A Receptor Type IB antibody - ab64813 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cells using ab64813 at a 1:500 dilution.Left image untreated.Right image treated with peptide.

Anti-Activin A Receptor Type IB antibody - ab185972 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-EFCAB4A antibody [EPR13742-78] (ab185952) at 1/500 dilutionLane 1 : SW480 cell extractLane 2 : 22RV-1 cell extractLane 3 : BT474 cell extract

Anti-Activin A Receptor Type IB antibody - ab169981 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Activin A Receptor Type IB antibody (ab169981) at 1/500 dilutionLane 1 : Human fetal kidney cell lysateLane 2 : Human fetal liver cell lysate

Anti-Activin A Receptor Type IB antibody - ab10594 from Abcam

Prices $378.00
Sizes 25 µg
Host Goat
Clonality Polyclonal
Human breast carcinoma tissue stained with ab10594 (5ug/ml). See recommended protocol for further details.

Anti-Activin A Receptor Type IB antibody - ab77049 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Activin A Receptor Type IB antibody (ab77049) at 1 µg/mlLane 1 : human kidney tissue lysateLane 2 : human kidney tissue lysate with blocking peptideLysates/proteins at 15 µg per lane.

Anti-Activin A Receptor Type IB antibody - ab37813 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Activin A Receptor Type IB antibody (ab37813) at 1/100 dilution + mouse kidney tissue lysate

Anti-Activin A Receptor Type IB antibody - ab196272 from Abcam

Prices $376.00
Sizes 250 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Activin A Receptor Type IB antibody (ab196272) at 1/500 dilutionLane 1 : Human fetal kidney lysatesLane 2 : Human fetal liver lysates

Anti-Activin A Receptor Type IB antibody - ab54953 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab54953 Activin A Receptor Type IB antibody at 1ug/ml.

Anti-Activin A Receptor Type IB antibody [EPR4815] - ab109300 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4815
Overlay histogram showing HEK293 cells stained with ab109300 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab109300, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was DyLight® 488 goat anti-rabbit IgG (H+L) (ab96899) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HEK293 cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Activin A Receptor Type IB antibody [EPR4816] - ab133478 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4816
All lanes : Anti-Activin A Receptor Type IB antibody [EPR4816] (ab133478) at 1/10000 dilutionLane 1 : HepG2 cell lysateLane 2 : SH SY5Y cell lysateLane 3 : U87 MG cell lysateLane 4 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Activin A Receptor Type IB antibody [MM0054-11A7] - ab78415 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0054-11A7
ab78415 at 1/50 dilution, staining Activin A Receptor Type IB in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

Anti-ACVR1B / ALK4 Antibody (Extracellular Domain, Biotin) - LS-C124877 from LifeSpan Bioscience

Prices $575.00
Sizes 500 µg
Host Goat
Clonality Polyclonal

Anti-ACVR1B / ALK4 Antibody (Extracellular Domain, Biotin) - LS-C124878 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-ACVR1B / ALK4 Antibody (Extracellular Domain) - LS-C126593 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ACVR1B / ALK4 Antibody (C-Terminus) - LS-C126594 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ACVR1B / ALK4 Antibody (Extracellular Domain) - LS-C124879 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ACVR1B / ALK4 Antibody (clone 179CT11.2.1, AP) - LS-C250082 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 179CT11.2.1

Anti-ACVR1B / ALK4 Antibody (clone 179CT11.2.1, APC) - LS-C250084 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 179CT11.2.1

Anti-ACVR1B / ALK4 Antibody (clone 179CT11.2.1, FITC) - LS-C250085 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 179CT11.2.1
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