| Gene Symbol | ACVR1B |
|---|---|
| Entrez Gene | 91 |
| Alt Symbol | ACTRIB, ACVRLK4, ALK4, SKR2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | activin A receptor, type IB |
| Other Description | activin A receptor, type II-like kinase 4|activin receptor type-1B|activin receptor-like kinase 4|serine/threonine-protein kinase receptor R2 |
| Swissprots | Q15481 B7Z5W5 B7Z5L8 Q15480 P36896 Q15482 Q15479 |
| Accessions | AAA53349 AAA53350 AAA53351 EAW58216 EAW58217 EAW58218 P36896 AK299120 BAH12954 AK299496 BAH13051 AL117643 BC000254 AAH00254 BC034008 BC040531 AAH40531 BT007072 AAP35735 EU831986 ACE87427 EU832079 ACE86741 L10125 AAA60555 L10126 AAA60556 U14722 AAA50246 Z22536 CAA80258 XM_011538966 XP_011537268 XM_011538967 XP_011537269 NM_004302 NP_004293 NM_020327 NP_064732 NM_020328 NP_064733 |
| Function | Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine- threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as AC |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. |
| Top Pathways | Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells |