ATP5A1

Gene Symbol	ATP5A1
Entrez Gene	498
Alt Symbol	ATP5A, ATP5AL2, ATPM, COXPD22, HEL-S-123m, MC5DN4, MOM2, OMR, ORM, hATP1
Species	Human
Gene Type	protein-coding
Description	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
Other Description	ATP synthase alpha chain, mitochondrial|ATP synthase subunit alpha, mitochondrial|ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle|ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non-cardiac muscle-like 2|ATP sythase (F1-ATPase) alpha subunit|epididymis secretory sperm binding protein Li 123m|mitochondrial ATP synthetase, oligomycin-resistant
Swissprots	A8K092 Q96IR6 B4DY56 Q53XX6 K7ENP3 Q9BTV8 Q8IXV2 Q96HW2 P25705 Q96FB4
Accessions	BAA05672 CAA48804 EAX01471 P25705 AK092735 BAG52604 AK098765 AK129739 AK129804 AK129900 AK289457 BAF82146 AK294804 BAG57924 AK302272 BAG63618 AK310051 AU120644 AU143001 AW205533 AW207528 BC003119 AAH03119 BC007299 AAH07299 BC008028 AAH08028 BC011384 AAH11384 BC016046 AAH16046 BC019310 AAH19310 BC028335 BC035703 BC039135 AAH39135 BC042694 BC064562 AAH64562 BC067385 AAH67385 BT007209 AAP35873 BT008250 AAP36942 CD244623 CK002707 D14710 BAA03531 DQ890557 ABM92174 DQ894210 ABM85136 FJ224309 ACI46001 X59066 CAA41789 X65460 CAA46452 XM_011526018 XP_011524320 NM_001001935 NP_001001935 NM_001001937 NP_001001937 NM_001257334 NP_001244263 NM_001257335 NP_001244264 NM_004046 NP_004037
Function	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). {ECO:0000250}.
Subcellular Location	Mitochondrion inner membrane. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Colocalizes with HRG on the cell surface of T-cells.
Tissue Specificity	Fetal lung, heart, liver, gut and kidney. Expressed at higher levels in the fetal brain, retina and spinal cord. {ECO:0000269|PubMed:8428659}.
Top Pathways	Alzheimer's disease, Huntington's disease, Oxidative phosphorylation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ATP5A full length protein - ab157931 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

ATP5A1 / ATP Synthase Alpha Antibody Blocking Peptide - LS-E10310 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ATP5A Protein - H00000498-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

ATP5A1-Antibody-C-term-Blocking-Peptide - BP9777c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human ATP5A1 protein - orb246215 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

ATP5A1 peptide - orb216948 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

alpha 1 Acid Glycoprotein protein - 30R-AA003 from Fitzgerald Category Protein Prices $295.00, $1,895.00 Sizes 10 mg, 100 mg

ORM protein - 30R-2078 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

ATP5A1 Blocking Peptide - abx062279 from Abbexa Category Peptide Species Human, Mouse, Rat

ATP synthase subunit alpha - H00000498-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

ATP5A1 fusion protein - ag6385 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ATP5A1 fusion protein - Ag8119 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human ATP5A1 protein, MYC/DDK-tagged - ATP5A1-8606H from Creative Biomart Category Protein Source HEK293 Species Human

ATP5A1 Blocking Peptide - CBP1085 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

ATP5A (K239) Peptide - BS3814P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant human ATP synthase subunit alpha, mitochondrial - CSB-EP002344HU CSB-BP002344HU CSB-MP002344HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant human ATP synthase subunit alpha, mitochondrial - CSB-YP002344HU from Cusabio Category Protein Source E.coli Species Human

Recombinant Human ATP synthase subunit alpha, mitochondrial(ATP5A1) - CSB-YP002344HU CSB-EP002344HU CSB-BP002344HU CSB-MP002344HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ATP synthase subunit alpha - TP314840 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ATP synthase subunit alpha, mitochondrial(ATP5A1) , Recombinant Protein - MBS957551 from MyBioSource Category Protein Prices $2,135.00, $2,135.00, $2,600.00, $2,600.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ATP5A1, Peptide - MBS428227 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

ATP5A Recombinant Protein Antigen - NBP2-38470PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ATP5A Recombinant Protein Antigen - NBP2-38525PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ATP5A1 Peptide, Human - M34GP01152H from Creative Peptides Category Peptide Source Synthetic. Species Human

ATP5A1 Recombinant Protein (OPCA01476) - OPCA01476 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

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