| Gene Symbol |
GRM3
|
| Entrez Gene |
2913
|
| Alt Symbol |
GLUR3, GPRC1C, MGLUR3, mGlu3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, metabotropic 3
|
| Other Description |
glutamate metabotropic receptor 3|metabotropic glutamate receptor 3
|
| Swissprots |
Q8TBH9 Q86YG6 Q75N17 Q75MV4 Q2PNZ6 Q14832
|
| Accessions |
AAC60379 AAD15616 EAL24182 EAW76971 EAW76972 Q14832 AK291406 BAF84095 AK294178 BAH11690 AK294701 BAH11851 BC022496 AAH22496 BC041407 AAH41407 DQ315361 ABC47402 DQ315362 DQ315363 DQ892396 ABM83322 DQ893287 ABM84213 DQ896619 ABM87618 EU432123 ABY87922 X77748 CAA54796 XM_011516088 XP_011514390 XM_011516089 XP_011514391 XM_011516090 XP_011514392 NM_000840 NP_000831
|
| Function |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:8840013}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:8840013}; Multi-pass membrane protein {ECO:0000269|PubMed:8840013}.
|
| Tissue Specificity |
Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala. {ECO:0000269|PubMed:8840013}.
|
| Top Pathways |
Glutamatergic synapse, Cocaine addiction, Neuroactive ligand-receptor interaction
|