TAP2

Gene Symbol	TAP2
Entrez Gene	6891
Alt Symbol	ABC18, ABCB3, APT2, D6S217E, PSF-2, PSF2, RING11
Species	Human
Gene Type	protein-coding
Description	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Other Description	ABC transporter, MHC 2|ATP-binding cassette, sub-family B (MDR/TAP), member 3|antigen peptide transporter 2|peptide supply factor 2|peptide transporter PSF2|peptide transporter involved in antigen processing 2|really interesting new gene 11 protein|transporter 2, ABC (ATP binding cassette)
Swissprots	Q9UQ83 Q96PT8 Q5HY71 O95410 B0V2J8 Q03519 Q53FI6
Accessions	AAG12163 AAL07496 AHW47924 AHW47941 AHW47958 AHW47975 BAA07665 BAA11414 CAA47027 CAA60788 EAX03642 EAX03643 Q03519 AB073779 BAB71769 AB208953 BAD92190 AF078671 AAD31384 AF105151 AAD12059 AF152583 AAD32715 AF176984 AAD50509 AK222823 BAD96543 AK223300 BAD97020 AK225657 AK225693 AK292963 BAF85652 AL833658 BC002751 BC152839 AAI52840 BG423357 BT009906 AAP88908 DC345324 EU832685 ACE87017 FM246456 CAR92541 L09191 AAA58648 L09271 L10287 AAA58649 M74447 AAA59841 M84748 U07844 AAA79901 Z22935 CAA80522 Z22936 CAA80523 NM_000544 NP_000535 NM_001290043 NP_001276972 NM_018833 NP_061313
Function	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane.
Top Pathways	ABC transporters, Primary immunodeficiency, Phagosome, Herpes simplex infection, Antigen processing and presentation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TAP2 Antibody - 12259 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

TAP2 (G-20) - sc-11473 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TAP2 (H-210) - sc-25612 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

TAP2B (Q-18) - sc-11470 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-TAP2 antibody - ab180611 from Abcam Prices $357.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TAP2 antibody - ab130414 from Abcam Prices $443.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TAP2 antibody - C-terminal - ab191067 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TAP2 Antibody (C-Terminus, AP) - LS-C283731 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TAP2 Antibody (C-Terminus, APC) - LS-C283732 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TAP2 Antibody (C-Terminus, Biotin) - LS-C283734 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TAP2 Antibody (C-Terminus, Azide-free, HRP) - LS-C283735 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TAP2 Antibody (C-Terminus, FITC) - LS-C283736 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TAP2 Antibody (C-Terminus, PE) - LS-C283738 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TAP2 Antibody (aa437-673) - LS-C311489 from LifeSpan Bioscience Prices $250.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TAP2 Antibody (aa667-686) - LS-C313233 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TAP2 Antibody (C-Terminus) - LS-C328939 from LifeSpan Bioscience Prices $425.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-TAP2 Antibody - LS-C193015 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TAP2 Antibody (clone TAP2.17) - LS-C179660 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone TAP2.17

Anti-TAP2 Antibody (aa689-703) IHC-plus™ - LS-B907 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TAP2 Antibody - LS-C331581 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

TAP2 Antibody (TAP2.17) - NBP1-54436 from Novus Biologicals Prices $279.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone TAP2.17

TAP2 Antibody - NBP1-89312 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PSF2 Antibody - NB100-75416 from Novus Biologicals Prices $399.00 Sizes 50 µg Host Chicken Clonality Polyclonal

TAP2 Antibody - NBP1-40335 from Novus Biologicals Prices $329.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

TAP2 Antibody - H00006891-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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