| Gene Symbol |
CXADR
|
| Entrez Gene |
1525
|
| Alt Symbol |
CAR, CAR4/6, HCAR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coxsackie virus and adenovirus receptor
|
| Other Description |
46 kD coxsackievirus and adenovirus receptor (CAR) protein|CVB3-binding protein|HCVADR|coxsackievirus B-adenovirus receptor|coxsackievirus and adenovirus receptor
|
| Swissprots |
D3YHP0 B7WPI3 Q8WWT8 P78310 B2R8V8 O00694 Q8WWT6 Q8WWT7 Q9UKV4
|
| Accessions |
AAF05908 AAF24344 AAG01088 EAX10030 EAX10031 EAX10032 EAX10033 P78310 AF124598 AAD31772 AI498294 AK313526 BAG36305 AY072910 AAL68878 AY072911 AAL68879 AY072912 AAL68880 BC003684 AAH03684 BC010536 AAH10536 BM547121 BT019876 AAV38679 CV570985 DQ891181 ABM82107 DQ894363 ABM85289 GU474812 ADC84500 U90716 AAC51234 Y07593 CAA68868 XM_011529475 XP_011527777 XM_011529476 XP_011527778 XM_011529477 XP_011527779 XM_011529478 XP_011527780 XM_011529479 XP_011527781 NM_001207063 NP_001193992 NM_001207064 NP_001193993 NM_001207065 NP_001193994 NM_001207066 NP_001193995 NM_001338 NP_001329
|
| Function |
Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:11734628, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:9096397}.
|
| Subcellular Location |
Isoform 5: Secreted.
|
| Tissue Specificity |
Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy. {ECO:0000269|PubMed:10490761, ECO:0000269|PubMed:11457744, ECO:0000269|PubMed:11549277, ECO:0000269|PubMed:9096397}.
|