| Gene Symbol | EIF5A |
|---|---|
| Entrez Gene | 1984 |
| Alt Symbol | EIF-5A, EIF5A1, eIF5AI |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 5A |
| Other Description | eIF-4D|eIF-5A-1|eIF-5A1|eukaryotic initiation factor 5A|eukaryotic translation initiation factor 5A-1|rev-binding factor |
| Swissprots | Q7Z4L1 Q7L7L3 D3DTP2 P63241 A8K9A0 |
| Accessions | AAA86989 AAB29229 EAW90219 EAW90220 EAW90221 EAW90222 P63241 AF087992 AF376057 AAL40917 AK222585 AK292615 BAF85304 AK303306 BAH13937 AY129319 AAN17514 AY129320 AAN17515 AY129321 AAN17516 AY129322 AAN17517 BC000751 AAH00751 BC001832 AAH01832 BC030160 AAH30160 BC080196 AAH80196 BC085015 AAH85015 BC107779 AAI07780 BG479628 CB111036 DQ892273 ABM83199 DQ895474 ABM86400 M23419 AAA58453 XM_005256509 XP_005256566 XM_011523708 XP_011522010 XM_011523709 XP_011522011 XM_011523710 XP_011522012 XM_011523711 XP_011522013 XM_011523712 XP_011522014 XM_011523713 XP_011522015 NM_001143760 NP_001137232 NM_001143761 NP_001137233 NM_001143762 NP_001137234 NM_001970 NP_001961 |
| Function | mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. {ECO:0000269|PubMed:15371445, ECO:0000269|PubMed:15452064, ECO:0000269|PubMed:16987817, ECO:0000269|PubMed:17187778, ECO:0000269|PubMed:17360499}. |
| Subcellular Location | Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. |
| Tissue Specificity | Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level). {ECO:0000269|PubMed:16519677}. |