| Gene Symbol |
Sstr2
|
| Entrez Gene |
20606
|
| Alt Symbol |
SSTR-2, Smstr-2, Smstr2, sst2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
somatostatin receptor 2
|
| Other Description |
SRIF-1|SS-2-R|SS2-R|SS2R|somatostatin receptor type 2
|
| Swissprots |
Q91Y73 P30875 P30934
|
| Accessions |
AAA58256 AAD01419 AAD01420 CAA06574 CBE74683 CBE74685 CDM63482 CDM63483 EDL34409 P30875 BC140348 AAI40349 BC146535 AAI46536 S71756 AAP20804 NM_001042606 NP_001036071 NM_009217 NP_033243
|
| Function |
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. {ECO:0000269|PubMed:8104154, ECO:0000269|PubMed:9507021}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:8104154}; Multi-pass membrane protein {ECO:0000269|PubMed:8104154}. Cytoplasm {ECO:0000250}. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Cerebrum and kidney.
|
| Top Pathways |
Gastric acid secretion, cAMP signaling pathway, Neuroactive ligand-receptor interaction
|
