MRE11A

Gene Symbol MRE11A
Entrez Gene 4361
Alt Symbol ATLD, HNGS1, MRE11, MRE11B
Species Human
Gene Type protein-coding
Description MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Other Description AT-like disease|DNA recombination and repair protein|MRE11 homolog 1|MRE11 homolog A|double-strand break repair protein MRE11A|endo/exonuclease Mre11|meiotic recombination 11 homolog 1|meiotic recombination 11 homolog A
Swissprots O43475 B3KTC7 P49959
Accessions AAK18790 AAS79320 CCQ43331 EAW66930 EAW66931 EAW66932 EAW66933 EAW66934 P49959 AF022778 AAD10197 AF073362 AAC36249 AK095388 BAG53039 AK308318 BC005241 AAH05241 BC017823 AAH17823 BC063458 AAH63458 BF574168 BT006730 AAP35376 JF432288 ADZ15505 U37359 AAC78721 XM_005274008 XP_005274065 XM_006718842 XP_006718905 XM_011542837 XP_011541139 XR_947828 NM_005590 NP_005581 NM_005591 NP_005582
Function Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
Subcellular Location Nucleus {ECO:0000250}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000250}.
Top Pathways Homologous recombination, Non-homologous end-joining

Human-MRE11A-cDNA-Clone - DC01677 from Abgent, a WuXi AppTec company

Prices $278.10
Sizes 10 µg
Species Human
Accession BC005241

MRE11A - MBS1274080 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC005241

Human MRE11A cDNA clone(NM_005590.3) - CDFH011724 from Creative Biomart

Species Human
Accession NM_005590.3

Human MRE11A cDNA clone(NM_005591.3) - CDFH011725 from Creative Biomart

Species Human
Accession NM_005591.3

Human MRE11A cDNA clone(NM_005591.3) - CDFH011726 from Creative Biomart

Species Human
Accession NM_005591.3

Human MRE11A ORF Clone(NM_005590.3) - CDCR290851 from Creative Biomart

Species Human
Accession NM_005590.3

Human MRE11A ORF Clone(NM_005590.3) - CDCR290852 from Creative Biomart

Species Human
Accession NM_005590.3

Human MRE11A ORF Clone(NM_005591.3) - CDCR290853 from Creative Biomart

Species Human
Accession NM_005591.3

Human MRE11A ORF Clone(NM_005591.3) - CDCR290854 from Creative Biomart

Species Human
Accession NM_005591.3

Human MRE11A ORF Clone(NM_005591.3) - CDCR290853 from Creative biogene

Species Human

Mouse MRE11A ORF clone (NM_005590.3) - CDCL133821 from Creative biogene

Species Human

Human MRE11A ORF Clone (BC005241) - CDCS412337 from Creative biogene

Species Human
Accession P49959

Human MRE11A cDNA Clone(NM_005590.3) - CDFH011724 from Creative biogene

Species Human

Human MRE11A cDNA Clone(NM_005591.3) - CDFH011725 from Creative biogene

Species Human

Human MRE11A cDNA Clone(NM_005591.3) - CDFH011726 from Creative biogene

Species Human
Search more