| Gene Symbol |
ELANE
|
| Entrez Gene |
1991
|
| Alt Symbol |
ELA2, GE, HLE, HNE, NE, PMN-E, SCN1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
elastase, neutrophil expressed
|
| Other Description |
PMN elastase|bone marrow serine protease|elastase 2, neutrophil|elastase-2|granulocyte-derived elastase|human leukocyte elastase|leukocyte elastase|medullasin|neutrophil elastase|polymorphonuclear elastase
|
| Swissprots |
P08246 Q6LDP5 P09649 Q6B0D9
|
| Accessions |
AAA36359 AAS89303 ACC78413 CAA68537 EAW69589 P08246 BC074816 AAH74816 BC074817 AAH74817 BI254663 D00187 BAA00128 J03545 AAA52378 M27783 AAA35792 M34379 AAA36173 X05875 CAA29299 XM_011527775 XP_011526077 XM_011527776 XP_011526078 XM_011546888 XP_011545190 NM_001972 NP_001963
|
| Function |
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. {ECO:0000269|PubMed:15140022}.
|
| Tissue Specificity |
Bone marrow cells.
|
| Top Pathways |
Systemic lupus erythematosus, Transcriptional misregulation in cancer
|