TDG

Gene Symbol TDG
Entrez Gene 6996
Alt Symbol hTDG
Species Human
Gene Type protein-coding
Description thymine-DNA glycosylase
Other Description G/T mismatch-specific thymine DNA glycosylase
Swissprots Q8IUZ6 Q13569 Q8IZM3
Accessions AAN16399 EAW97727 EAW97728 EAW97729 Q13569 AI004247 AI452763 AK295387 BAG58341 AK299832 BAG61699 AK303631 BAG64639 AK309792 AK311673 AK313234 BAG36045 AL710869 BC001307 BC010945 BC019925 AAH19925 BC037557 AAH37557 BC071714 BC104477 AAI04478 CB047650 CN274338 DB162106 DN601672 DQ786320 XM_005269125 XP_005269182 XM_011538714 XP_011537016 XM_011538715 XP_011537017 XR_429113 NM_003211 NP_003202 NM_001008411
Function DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5- hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5- methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar- phosphate backbone of the DNA and a mispaired thymine. In addition t
Subcellular Location Nucleus {ECO:0000269|PubMed:8662714}.
Top Pathways Base excision repair

Human TDG / Thymine DNA Glycosylase ELISA Kit (Sandwich ELISA) - LS-F6753 from LifeSpan Bioscience

Category ELISA Kit
Prices $720.00
Sizes 1 plate
Sensitivity 0.121 ng/ml
Range 0.313-20 ng/ml

Thymine DNA Glycosylase (TDG), Human, ELISA Kit - SEH053Hu from ARP American Research Products

Category ELISA Kit
Prices $720.00
Sizes 96 t
Sensitivity 0.038ng/mL
Range 0.312-20ng/mL

thymine-DNA glycosylase, ELISA Kit - MBS9323191 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Thymine DNA Glycosylase (TDG) - SEH053Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.121ng/mL.
Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Thymine DNA Glycosylase (TDG) - SEH053Hu from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.121ng/mL.
Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human TDG ELISA Kit - abx153242 from Abbexa

Category ELISA Kit
Sensitivity 0.121 ng/ml
Range 0.313 ng/ml - 20 ng/ml

Thymine DNA Glycosylase (TDG), Human, ELISA Kit - DL-TDG-Hu from ARP American Research Products

Category ELISA Kit
Prices $655.00
Sizes 96 t
Range 0.312-20 ng/mL

Human TDG ELISA Kit - abx572421 from Abbexa

Category ELISA Kit
Sensitivity 0.038 ng/ml
Range 0.313 ng/ml - 20 ng/ml

Human TDG ELISA Kit - E038175 from Biobool

Category ELISA Kit
Sensitivity Typically less than 0.121ng/mL.

TDG ELISA Kit (Human) (OKCD01940) - OKCD01940 from Aviva Systems Biology

Category ELISA Kit
Prices $545.00
Sizes 96 wells
Sensitivity < 0.121 ng/mL
Range 0.312 - 20 ng/mL

Thymine DNA Glycosylase (TDG), ELISA Kit - MBS453822 from MyBioSource

Category ELISA Kit
Prices $415.00, $550.00, $2,425.00, $4,710.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity <0.121ng/mL
Range 0.312-20ng/mL
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