| Gene Symbol |
Srebf1
|
| Entrez Gene |
20787
|
| Alt Symbol |
ADD-1, ADD1, D630008H06, SREBP-1, SREBP-1a, SREBP-1c, SREBP1, SREBP1c, bHLHd1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
sterol regulatory element binding transcription factor 1
|
| Other Description |
adipocyte determination- and differentiation-dependent factor 1|sterol regulatory element-binding protein 1
|
| Swissprots |
Q9WTN3 Q99JK7 Q3UDJ3 Q5SRX5 Q8C733 Q3U458
|
| Accessions |
EDL26614 EDL26615 EDL26616 Q9WTN3 AB017337 BAA74795 AF374266 AAK54762 AK040663 AK052628 BAC35068 AK150052 BAE29268 AK154424 BAE32576 AK158269 BAE34440 AK169607 BAE41256 AK194244 AK198337 AK205046 AK209898 AK216773 BC006051 AAH06051 BC056922 AAH56922 XM_006532713 XP_006532776 XM_006532714 XP_006532777 XM_006532715 XP_006532778 XM_006532716 XP_006532779 XM_006532717 XP_006532780 XM_011248845 XP_011247147 NM_011480 NP_035610
|
| Function |
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE- 1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC- 3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. {ECO:0000269|PubMed:11782483, ECO:0000269|PubMed:12855691, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:9329978, ECO:0000269|PubMed:9784493}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:21459323}; Multi-pass membrane protein {ECO:0000269|PubMed:21459323}. Golgi apparatus membrane {ECO:0000269|PubMed:21459323}; Multi-pass membrane protein {ECO:0000269|PubMed:21459323}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:21459323}; Multi-pass membrane protein {ECO:0000269|PubMed:21459323}. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
|
| Tissue Specificity |
Isoform SREBP-1C predominates in liver, adrenal gland, brain and adipose tissue, whereas isoform SREBP-1A predominates in spleen. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, thymus, testis, muscle, jejunum, and ileum.
|
| Top Pathways |
Insulin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway
|