| Gene Symbol |
Csf1
|
| Entrez Gene |
12977
|
| Alt Symbol |
C87615, Csfm, MCSF, op
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
colony stimulating factor 1 (macrophage)
|
| Other Description |
macrophage colony-stimulating factor 1|osteopetrosis
|
| Swissprots |
P07141 Q8R3C8 Q3U395
|
| Accessions |
AAA19866 EDL01915 EDL01916 EDL01917 EDL01918 EDL01919 P07141 AI844210 AK136808 AK138489 BAE23681 AK154261 BAE32472 AK154872 BAE32893 AK160995 BAE36140 AK166370 BAE38736 AK170154 BAE41601 BC025593 AAH25593 BC066187 AAH66187 BC066200 AAH66200 BC066205 AAH66205 CA328312 M15692 AAA37480 M21149 AAA37482 M21952 AAA37481 S78392 AAB34634 X05010 CAA28660 NM_001113529 NP_001107001 NM_001113530 NP_001107002 NM_007778 NP_031804
|
| Function |
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Osteoclast differentiation, Rheumatoid arthritis, PI3K-Akt signaling pathway
|