CDK9

Gene Symbol	CDK9
Entrez Gene	1025
Alt Symbol	C-2k, CDC2L4, CTK1, PITALRE, TAK
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 9
Other Description	CDC2-related kinase|cell division cycle 2-like protein kinase 4|cell division protein kinase 9|serine/threonine protein kinase PITALRE|tat-associated kinase complex catalytic subunit
Swissprots	Q96TF1 P50750 Q5JU24 Q5U006 Q5JU25
Accessions	AAF72183 AAM54039 EAW87696 EAW87697 P50750 AB451289 BAG70103 AB451421 BAG70235 AK313828 BAG36563 BC001968 AAH01968 BE549667 BT019903 AAV38706 BX091973 DB120461 DQ891182 ABM82108 DQ894364 ABM85290 DQ894365 ABM85291 L25676 AAA35668 X80230 CAA56516 NM_001261 NP_001252
Function	Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modificatio
Subcellular Location	Nucleus. Cytoplasm. Nucleus, PML body. Note=Accumulates on chromatin in response to replication stress. Complexed with CCNT1 in nuclear speckles, but uncomplexed form in the cytoplasm. The translocation from nucleus to cytoplasm is XPO1/CRM1-dependent. Associates with PML body when acetylated.
Tissue Specificity	Ubiquitous.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rabbit anti-CDK9 Antibody, Affinity Purified - PLA0281 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Cyclin Dependent Kinase 9, CDK9, Human, ELISA Kit - E-EL-H2326 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cyclin Dependent Kinase 9, CDK9, Mouse, ELISA Kit - E-EL-M0378 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin Dependent Kinase 9, CDK9, Rat, ELISA Kit - E-EL-R0292 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin Dependent Kinase 9, CDK9, Rabbit, ELISA Kit - E-EL-RB1543 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin Dependent Kinase 9, CDK9, Chicken, ELISA Kit - E-EL-Ch0180 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Cyclin Dependent Kinase 9, CDK9, Porcine, ELISA Kit - E-EL-P1743 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin Dependent Kinase 9, CDK9, Monkey, ELISA Kit - E-EL-MK2165 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human CDK9 ELISA Kit - HC0651 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine CDK9 ELISA Kit - AC0651 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

CDK9, ELISA Kit - MBS2513411 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

CDK9, ELISA Kit - MBS2514987 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.375ng/mL Range 0.625-40ng/mL

CDK9, ELISA Kit - MBS2501429 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.875ng/mL Range 3.125-200ng/mL

CDK9, ELISA Kit - MBS2509147 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

CDK9, ELISA Kit - MBS2500195 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

CDK9, ELISA Kit - MBS2513840 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

CDK9, ELISA Kit - MBS2502653 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.938ng/mL Range 1.563-100ng/mL

Human CDK9(Cyclin Dependent Kinase 9) ELISA Kit - E-EL-H2326 from Elabscience Category ELISA Kit Sensitivity 0.94 ng/mL Range 1.56—100 ng/mL

Cyclin Dependent Kinase 9, ELISA Kit - MBS754692 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin Dependent Kinase 9, ELISA Kit - MBS041733 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin Dependent Kinase 9, ELISA Kit - MBS047621 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin Dependent Kinase 9, ELISA Kit - MBS054314 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin Dependent Kinase 9, ELISA Kit - MBS728882 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin Dependent Kinase 9, ELISA Kit - MBS732724 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin Dependent Kinase 9, ELISA Kit - MBS037186 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Search more