| Gene Symbol |
PARD3
|
| Entrez Gene |
56288
|
| Alt Symbol |
ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
par-3 family cell polarity regulator
|
| Other Description |
CTCL tumor antigen se2-5|PAR3-alpha|atypical PKC isotype-specific interacting protein|atypical PKC isotype-specific-interacting protein|bazooka|par-3 family cell polarity regulator alpha|par-3 partitioning defective 3 homolog|partitioning defective 3 homolog|protein phosphatase 1, regulatory subunit 118
|
| Swissprots |
Q5T2U1 Q9NWL4 Q96K28 Q96RM7 Q8TEW2 Q5VWV5 Q5VWV3 Q9HC48 Q5VWV0 Q96RM6 F5H5T0 Q9BY58 Q6IQ47 Q8TEW1 Q9NYE6 Q5VWV4 Q9BY57 Q8TEW3 Q8TEW0
|
| Accessions |
EAW85932 EAW85933 EAW85934 Q8TEW0 AA136967 AB073671 BAC54037 AF177228 AAG33676 AF196185 AAK27891 AF196186 AAK27892 AF252293 AAF71530 AF332592 AAK69192 AF332593 AAK69193 AF454057 AAN75697 AF454058 AAN75698 AF454059 AAN75699 AF467002 AAL76042 AF467003 AAL76043 AF467004 AAL76044 AF467005 AAL76045 AF467006 AAL76046 AK000761 BAA91366 AK024668 AK025892 AK027735 BAB55330 AK172827 AW242451 BC011711 AAH11711 BC071566 AAH71566 BE464617 BM796605 XM_005252528 XP_005252585 XM_005252530 XP_005252587 XM_005252531 XP_005252588 XM_005252532 XP_005252589 XM_005252534 XP_005252591 XM_005252535 XP_005252592 XM_005252536 XP_005252593 XM_011519569 XP_011517871 XM_011519570 XP_011517872 XM_011519571 XP_011517873 XM_011519572 XP_011517874 XM_011519573 XP_011517875 XM_011519574 XP_011517876 XM_011519575 XP_011517877 XM_011519576 XP_011517878 XM_011519577 XP_011517879 XM_011519578 XP_011517880 XM_011519579 XP_011517881 XM_011519580 XP_011517882 XM_011519581 XP_011517883 XM_011519582 XP_011517884 XM_011519583 XP_011517885 XM_011519584 XP_011517886 NM_001184785 NP_001171714 NM_001184786 NP_001171715 NM_001184787 NP_001171716 NM_001184788 NP_001171717 NM_001184789 NP_001171718 NM_001184790 NP_001171719 NM_001184791 NP_001171720 NM_001184792 NP_001171721 NM_001184793 NP_001171722 NM_001184794 NP_001171723 NM_019619 NP_062565
|
| Function |
Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:19812038}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Endomembrane system {ECO:0000269|PubMed:20332120}. Cell junction {ECO:0000269|PubMed:20332120}. Cell junction, tight junction {ECO:0000269|PubMed:20332120}. Cell membrane {ECO:0000269|PubMed:20332120}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20332120}. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Colocalized with SIRT2 in internode region of myelin sheat (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:12234671}.
|
| Top Pathways |
Adherens junction, Tight junction, Endocytosis, Chemokine signaling pathway, Hippo signaling pathway
|