| Gene Symbol | CA9 |
|---|---|
| Entrez Gene | 768 |
| Alt Symbol | CAIX, MN |
| Species | Human |
| Gene Type | protein-coding |
| Description | carbonic anhydrase IX |
| Other Description | CA-IX|P54/58N|RCC-associated antigen G250|RCC-associated protein G250|carbonate dehydratase IX|carbonic anhydrase 9|carbonic dehydratase|membrane antigen MN|pMW1|renal cell carcinoma-associated antigen G250 |
| Swissprots | Q5T4R1 Q16790 |
| Accessions | CBL94025 EAW58359 Q16790 AI023541 AJ010588 CAB82444 AL554705 BC014950 AAH14950 DQ892208 ABM83134 DQ895404 ABM86330 EF122496 ABL67717 X66839 CAA47315 XM_006716869 XP_006716932 XM_006716870 XP_006716933 XR_428428 NM_001216 NP_001207 |
| Function | Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia. {ECO:0000269|PubMed:18703501}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:8486430}. Nucleus, nucleolus {ECO:0000269|PubMed:8486430}. Cell membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Cell projection, microvillus membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus. |
| Tissue Specificity | Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa. |
| Top Pathways | Nitrogen metabolism |