CHMP2A

Gene Symbol	CHMP2A
Entrez Gene	27243
Alt Symbol	BC-2, BC2, CHMP2, VPS2, VPS2A
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 2A
Other Description	VPS2 homolog A|charged multivesicular body protein 2a|chromatin modifying protein 2A|putative breast adenocarcinoma marker (32kD)|putative breast adenocarcinoma marker BC-2|vacuolar protein sorting-associated protein 2-1|vps2-1
Swissprots	Q3ZTT0 B2R4W6 O43633
Accessions	CAC14310 EAW72608 EAW72609 EAW72610 EAW72611 O43633 AF042384 AAC00005 AK092868 AK311974 BAG34913 AY364248 AAQ76807 BC002502 AAH02502 BC047005 BE856471 BG546479 BI457978 BP315111 BT007298 AAP35962 BU147101 CN305066 CR457002 CAG33283 DQ892587 ABM83513 DQ895805 ABM86731 XM_005258746 XP_005258803 XM_005258747 XP_005258804 NM_014453 NP_055268 NM_198426 NP_940818
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities,
Subcellular Location	Late endosome membrane {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}; Peripheral membrane protein {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}; Cytoplasmic side {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CHMP2A-Over-expression-Lysate - LY13900a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

CHMP2A / BC2 Lysate(Denatured) - H00027243-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

CHMP2A 293 Cell Lysate - 403464 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CHMP2A Overexpression Lysate (Denatured) - H00027243-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

CHMP2A Overexpression Lysate (Native) - NBL1-09159 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CHMP2A Overexpression Lysate (Native) - NBP2-07330 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CHMP2A Over-expression Lysate Product - GWB-705D80 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

CHMP2A Overexpression Lysate (Native) - NBP2-09864 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CHMP2A Overexpression Lysate (Denatured) - H00027243-T03 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human CHMP2A Knockdown Stable Cell Line - CSC-DC003102 from Creative biogene Category Cell Line Species Human

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