| Gene Symbol |
Tead3
|
| Entrez Gene |
21678
|
| Alt Symbol |
DTEF-1, ETFR-1, TEAD-3, TEF-5, Tcf13r2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
TEA domain family member 3
|
| Other Description |
ETF-related factor 1|transcriptional enhancer factor TEF-5
|
| Swissprots |
O70623 O08516 P70209 P70210
|
| Accessions |
CAB38080 EDL22570 EDL22571 EDL22572 EDL22573 P70210 AF002670 AAC12263 AK031555 BAC27448 AK087649 AK143551 BC021364 AAH21364 BC027383 AAH27383 BC039984 AAH39984 BC047929 BC146313 AAI46314 BC156574 AAI56575 CB182196 CF617964 D87963 BAA13516 D87964 BAA13517 Y10027 CAA71136 Y16611 CAA76315 NM_001098226 NP_001091696 NM_001204156 NP_001191085 NM_011566 NP_035696
|
| Function |
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Expressed in embryos as well as in many adult tissues.
|
| Top Pathways |
Hippo signaling pathway
|