HPSE

Gene Symbol HPSE
Entrez Gene 10855
Alt Symbol HPA, HPA1, HPR1, HPSE1, HSE1
Species Human
Gene Type protein-coding
Description heparanase
Other Description endo-glucoronidase|heparanase-1
Swissprots Q53GE5 E9PCA9 C7F7I4 Q9Y251 E9PGR1 Q9UL39 C7F7I3 A9JIG7
Accessions CAH05691 CAH05695 CAI40110 EAX05932 EAX05933 Q9Y251 AF084467 AAD54516 AF144325 AAD41342 AF152376 AAD45669 AF155510 AAD54941 AF165154 AAD45379 AJ627581 CAF28887 AK075400 BAG52128 AK090910 AK222986 BAD96706 AM419200 CAL91960 AW293069 AY948074 AAX47106 BC029464 BC051321 AAH51321 FJ517659 FJ517660 GQ337901 ACT98237 GQ337902 ACT98238 HM187643 ADK11282 NM_001098540 NP_001092010 NM_001166498 NP_001159970 NM_001199830 NP_001186759 NM_006665 NP_006656
Function Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation fa
Subcellular Location Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Associates with lipid rafts. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity). {ECO:0000250}.
Tissue Specificity Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. Also expressed in hair follicles, specifically in both Henle's and Huxley's layers of inner the root sheath (IRS) at anagen phase. {ECO:0000269|PubMed:10395326, ECO:0000269|PubMed:10405343, ECO:0000269|PubMed:10764835, ECO:0000269|PubMed:18557927, ECO:0000269|PubMed:20309870}.
Top Pathways Proteoglycans in cancer, Glycosaminoglycan degradation

HPA1 (H-80) - sc-25825 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HPA1 (H-80): sc-25825. Immunoperoxidase staining of formalin fixed, paraffin-embedded human stomach tissue showing cytoplasmic staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

HPA1 (L-19) - sc-26136 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Heparanase 1 antibody - ab85543 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Heparanase 1 antibody - ab109696 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-Heparanase 1 antibody (ab109696) at 1/500 dilutionLane 1 : HepG2 cell lysateLane 2 : MCF-7 cell lysate

Anti-Heparanase 1 antibody - ab56781 from Abcam

Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56781 Heparanase 1 antibody at 1ug/ml.

Anti-Heparanase 1 antibody [EPR4273(2)] - ab128931 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EPR4273(2)
All lanes : Anti-Heparanase 1 antibody [EPR4273(2)] (ab128931) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : Jurkat cell lysateLane 3 : HepG2 cell lysateLane 4 : 293T cell lysateLane 5 : SH-SY5Y cell lysateLane 6 : C6 cell lysateLane 7 : PC12 cell lysateLane 8 : NIH 3T3 cell lysateLysates/proteins at 10 µg/ml per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-HPSE / Heparanase Antibody (aa26-54, AP) - LS-C258872 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HPSE / Heparanase Antibody (N-Terminus) - LS-C172010 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HPSE / Heparanase Antibody (aa26-54, APC) - LS-C258873 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HPSE / Heparanase Antibody (aa26-54, Biotin) - LS-C258874 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HPSE / Heparanase Antibody (aa26-54, PE) - LS-C259860 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HPSE / Heparanase Antibody (aa26-54, Azide-free, HRP) - LS-C258875 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HPSE / Heparanase Antibody (aa26-54, FITC) - LS-C258876 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HPSE / Heparanase Antibody (aa26-54) - LS-C157818 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
HPSE Antibody western blot of U251 cell line lysates (35 ug/lane). The HPSE antibody detected the HPSE protein (arrow).

Anti-HPSE / Heparanase Antibody (aa68-117) IHC-plus™ - LS-B8258 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HPSE / Heparanase antibody IHC of human colon, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8258 dilution 5-10 ug/mg lysate.

Anti-HPSE / Heparanase Antibody (aa34-115, Biotin) - LS-C297230 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HPSE / Heparanase Antibody (aa400-543, Biotin) - LS-C297564 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HPSE / Heparanase Antibody (aa280-412, Biotin) - LS-C297565 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HPSE / Heparanase Antibody (aa353-464, Biotin) - LS-C299254 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HPSE / Heparanase Antibody (aa419-535, Biotin) - LS-C299255 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HPSE / Heparanase Antibody (aa280-412) - LS-C294463 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant HPSE / Heparanase.

Anti-HPSE / Heparanase Antibody (aa54-278, Biotin) - LS-C299257 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HPSE / Heparanase Antibody (aa419-535, Biotin) - LS-C299662 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HPSE / Heparanase Antibody (aa400-543) - LS-C294462 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant HPSE / Heparanase.

Anti-HPSE / Heparanase Antibody (aa419-535, FITC) - LS-C302559 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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