| Gene Symbol |
Polr2c
|
| Entrez Gene |
20021
|
| Alt Symbol |
33kDa, RPB3, Rpo2-3, mRBP31
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
polymerase (RNA) II (DNA directed) polypeptide C
|
| Other Description |
DNA-directed RNA polymerase II 33 kDa polypeptide|DNA-directed RNA polymerase II subunit C|DNA-directed RNA polymerase II subunit RPB3|RNA polymerase II 3|RNA polymerase II subunit 3|RNA polymerase II subunit B3|RPB31|RPB33
|
| Swissprots |
P97760
|
| Accessions |
P97760 AK137796 BAE23500 AK146763 BAE27415 AK151270 BAE30257 AK160053 BAE35592 AK192118 BC002023 AAH02023 BC099548 AAH99548 D83999 BAA12205 NM_009090 NP_033116
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Top Pathways |
Huntington's disease, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism
|