NMNAT2

Gene Symbol NMNAT2
Entrez Gene 23057
Alt Symbol C1orf15, PNAT2
Species Human
Gene Type protein-coding
Description nicotinamide nucleotide adenylyltransferase 2
Other Description NMN adenylyltransferase 2|NMN/NaMN adenylyltransferase 2|NaMN adenylyltransferase 2|nicotinamide mononucleotide adenylyltransferase 2|nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2|nicotinate-nucleotide adenylyltransferase 2|pyridine nucleotide adenylyltransferase 2
Swissprots Q96QW1 O75067 Q9BZQ4 Q5T1Q3 Q8WU99
Accessions CAM12698 CDH92522 EAW91148 EAW91149 EAW91150 EAW91151 Q9BZQ4 AB007948 BAA32324 AF086038 AF288395 AAG60615 AK291390 BAF84079 AK309461 BC016726 BC020998 AAH20998 BC037251 BI493003 HQ447356 ADQ31842 NM_015039 NP_055854 NM_170706 NP_733820
Function Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). {ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:16118205}. Golgi apparatus {ECO:0000269|PubMed:16118205}.
Tissue Specificity Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. {ECO:0000269|PubMed:12359228, ECO:0000269|PubMed:14516279, ECO:0000269|PubMed:16118205}.
Top Pathways Nicotinate and nicotinamide metabolism

NMNAT-2 CRISPR/Cas9 KO Plasmid (h) - sc-403330 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-2 HDR Plasmid (h) - sc-403330-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-2 Double Nickase Plasmid (h) - sc-403330-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-2 Double Nickase Plasmid (h2) - sc-403330-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-2 CRISPR Activation Plasmid (h) - sc-403330-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-2 CRISPR Activation Plasmid (h2) - sc-403330-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-2 Lentiviral Activation Particles (h) - sc-403330-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-2 Lentiviral Activation Particles (h2) - sc-403330-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-2 siRNA (h) - sc-62693 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NMNAT-2 shRNA Plasmid (h) - sc-62693-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NMNAT-2 shRNA (h) Lentiviral Particles - sc-62693-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NMNAT-2 RNAi - H00023057-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

NMNAT-2 RNAi - H00023057-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU058901 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15376 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15376 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NMNAT2 siRNA (Human) - CRH7965 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NMNAT2 (NM_015039.3) - SHH353236 from Creative biogene

Category siRNA
Species Reactivities Human

Human NMNAT2 siRNA - orb268467 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NMNAT2 shRNA Plasmid (Human) - CHH7965 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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