| Gene Symbol |
APBB1
|
| Entrez Gene |
322
|
| Alt Symbol |
FE65, MGC:9072, RIR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
|
| Other Description |
adaptor protein FE65a2|amyloid beta A4 precursor protein-binding family B member 1|stat-like protein
|
| Swissprots |
D3DQT2 B7Z1J5 A6NL69 V9GYT4 V9GYK0 A1E379 B7Z2Y0 Q96A93 B7Z1J6 O00213 A6NH82 Q7Z324
|
| Accessions |
AAC79942 EAW68722 EAW68723 EAW68724 EAW68725 O00213 AF394214 AAL79526 AK098207 AK293452 BAH11511 AK293550 BAH11531 AK293554 BAH11532 AK293613 BAH11546 AK293643 BAH11554 AK293711 BAH11576 AK294495 BAH11788 AK295241 BAH12016 AK295425 BAH12063 AK295837 BAH12197 AK297542 BAH12610 AK297544 BAH12612 AK297550 BAH12615 AK308559 AK308782 AK309000 AK309434 AK309445 AK311091 AK311101 AK311141 AK311149 AK311413 AK311725 AK315965 BAH14336 BC010854 AAH10854 BG333769 BG699532 BM145723 BX538185 CAD98057 DC303314 DC306210 DC316489 DC319935 DQ890997 ABM81923 DQ894175 ABM85101 EF103274 ABL07489 HY118301 HY138432 HY145957 L77864 AAB93631 XM_006718209 XP_006718272 XM_006718210 XP_006718273 XM_006718211 XP_006718274 XM_006718212 XP_006718275 XM_006718213 XP_006718276 XM_006718214 XP_006718277 XM_006718215 XP_006718278 XM_011520037 XP_011518339 XM_011520038 XP_011518340 XM_011520039 XP_011518341 XM_011520040 XP_011518342 XM_011520041 XP_011518343 XM_011520042 XP_011518344 NM_001164 NP_001155 NM_001257319 NP_001244248 NM_001257320 NP_001244249 NM_001257321 NP_001244250 NM_001257323 NP_001244252 NM_001257325 NP_001244254 NM_001257326 NP_001244255 NM_145689 NP_663722 NR_047512 NM_001257322 NM_001257324
|
| Function |
Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro- apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). {ECO:0000269|PubMed:
|
| Subcellular Location |
Cell membrane. Cytoplasm. Nucleus. Cell projection, growth cone {ECO:0000250}. Nucleus speckle. Note=Colocalizes with TSHZ3 in axonal growth cone (By similarity). In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP. Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus. Nuclear translocation is under the regulation of APP. Colocalizes with TSHZ3 in the nucleus. Colocalizes with NEK6 at the nuclear speckles. Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease. {ECO:0000269|PubMed:19343227}.
|
| Top Pathways |
Alzheimer's disease
|