SRP68

Gene Symbol SRP68
Entrez Gene 855833
Alt Symbol -
Species Yeast
Gene Type protein-coding
Description Srp68p
Other Description -
Swissprots P38687 D6W3C8
Accessions DAA11194 P38687 NM_001184057 NP_015081
Function Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:11352936}.
Top Pathways Protein export