| Gene Symbol |
Mapk14
|
| Entrez Gene |
81649
|
| Alt Symbol |
CRK1, CSBP, CSPB1, Csbp1, Csbp2, Exip, Hog, Mxi2, Prkm14, Prkm15, RK, Sapk2A, p38, p38Hog, p38alpha
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
mitogen activated protein kinase 14
|
| Other Description |
Csaids binding protein|MAP kinase 14|MAP kinase 2|MAP kinase Mxi2|MAP kinase p38 alpha|MAPK 14|MAX-interacting protein 2|cytokine suppressive anti-inflammatory drug binding protein|cytokine-supressive anti-inflammatory drug binding protein|mitogen-activated protein kinase 14|mitogen-activated protein kinase 14A|mitogen-activated protein kinase p38 alpha|p38 MAP kinase|p38 mitogen activated protein kinase|p38alpha Exip|reactive kinase|stress-activated protein kinase 2A
|
| Swissprots |
P70618 O08594 Q99MG4
|
| Accessions |
EDL96934 EDL96935 EDL96936 EDL96937 P70618 AB000783 BAF80890 AF346293 AAK15541 BC092193 AAH92193 U73142 AAC71059 U91847 AAB51285 XM_006256142 XP_006256204 NM_031020 NP_112282
|
| Function |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mito
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Top Pathways |
Inflammatory mediator regulation of TRP channels, Prolactin signaling pathway, Adrenergic signaling in cardiomyocytes, TNF signaling pathway, Signaling pathways regulating pluripotency of stem cells
|